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Titel: Role of Specific B-Cell Receptor Antigens in Lymphomagenesis
VerfasserIn: Thurner, Lorenz
Hartmann, Sylvia
Neumann, Frank
Hoth, Markus
Stilgenbauer, Stephan
Küppers, Ralf
Preuss, Klaus-Dieter
Bewarder, Moritz
Sprache: Englisch
Titel: Frontiers in Oncology
Bandnummer: 10
Verlag/Plattform: Frontiers
Erscheinungsjahr: 2020
Freie Schlagwörter: B-cell receptor
antigen
lymphoma
autoreactivity
posttransnational modification
antigens of infectious origin
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The B-cell receptor (BCR) signaling pathway is a crucial pathway of B cells, both for their survival and for antigen-mediated activation, proliferation and differentiation. Its activation is also critical for the genesis of many lymphoma types. BCR-mediated lymphoma proliferation may be caused by activating BCR-pathway mutations and/or by active or tonic stimulation of the BCR. BCRs of lymphomas have frequently been described as polyreactive. In this review, the role of specific target antigens of the BCRs of lymphomas is highlighted. These antigens have been found to be restricted to specific lymphoma entities. The antigens can be of infectious origin, such as H. pylori in gastric MALT lymphoma or RpoC of M. catarrhalis in nodular lymphocyte predominant Hodgkin lymphoma, or they are autoantigens. Examples of such autoantigens are the BCR itself in chronic lymphocytic leukemia, LRPAP1 in mantle cell lymphoma, hyper-N-glycosylated SAMD14/neurabin-I in primary central nervous system lymphoma, hypo-phosphorylated ARS2 in diffuse large B-cell lymphoma, and hyper-phosphorylated SLP2, sumoylated HSP90 or saposin C in plasma cell dyscrasia. Notably, atypical posttranslational modifications are often responsible for the immunogenicity of many autoantigens. Possible therapeutic approaches evolving from these specific antigens are discussed.
DOI der Erstveröffentlichung: 10.3389/fonc.2020.604685
URL der Erstveröffentlichung: https://doi.org/10.3389/fonc.2020.604685
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-425269
hdl:20.500.11880/38157
http://dx.doi.org/10.22028/D291-42526
ISSN: 2234-943X
Datum des Eintrags: 2-Aug-2024
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Biophysik
M - Innere Medizin
Professur: M - Prof. Dr. Markus Hoth
M - Prof. Dr. Stephan Stilgenbauer
M - Dr. med. Lorenz Thurner
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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