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Titel: Of Humans and Gerbils- Independent Diversification of Neuroligin-4 Into X- and Y-Specific Genes in Primates and Rodents
VerfasserIn: Maxeiner, Stephan
Benseler, Fritz
Brose, Nils
Krasteva-Christ, Gabriela
Sprache: Englisch
Titel: Frontiers in Molecular Neuroscience
Bandnummer: 15
Verlag/Plattform: Frontiers
Erscheinungsjahr: 2022
Freie Schlagwörter: gametologous genes
pseudoautosomal region (PAR)
euarchontoglires
gerbils
neuroligin-4
mammal evolution
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The neural cell adhesion protein neuroligin-4 has puzzled neuroscientists and geneticist alike for almost two decades. Its clinical association with autism spectrum disorders (ASD) is well established, however, its diversification into sex chromosome-specific copies, NLGN4X and NLGN4Y, remains uncharted territory. Just recently, the presence of substantial neuroligin-4 sequence differences between humans and laboratory mice, in which Nlgn4 is a pseudoautosomal gene, could be explained as a consequence of dramatic changes affecting the pseudoautosomal region on both sex chromosomes in a subset of rodents, the clade eumuroida. In this study, we describe the presence of sex chromosome-specific copies of neuroligin-4 genes in the Mongolian gerbil (Meriones unguiculatus) marking the first encounter of its kind in rodents. Gerbils are members of the family Muridae and are closely related to mice and rats. Our results have been incorporated into an extended evolutionary analysis covering primates, rodents, lagomorphs, treeshrews and culogos comprising together the mammalian superorder euarchontoglires. We gathered evidence that substantial changes in neuroligin-4 genes have also occurred outside eumuroida in other rodent species as well as in lagomorphs. These changes feature, e.g., a general reduction of its gene size, an increase in its average GC-content as well as in the third position (GC3) of synonymous codons, and the accumulation of repetitive sequences in line with previous observations. We further show conclusively that the diversification of neuroligin-4 in sex chromosomespecific copies has happened multiple times independently during mammal evolution proving that Y-chromosomal NLGN4Y genes do not originate from a single common NLGN4Y ancestor.
DOI der Erstveröffentlichung: 10.3389/fnmol.2022.838262
URL der Erstveröffentlichung: https://doi.org/10.3389/fnmol.2022.838262
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-422422
hdl:20.500.11880/37928
http://dx.doi.org/10.22028/D291-42242
ISSN: 1662-5099
Datum des Eintrags: 24-Jun-2024
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_1.xlsx/838262_supplementary-materials_datasheets_1_xlsx/3?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_2.xlsx/838262_supplementary-materials_datasheets_2_xlsx/3?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_3.docx/838262_supplementary-materials_datasheets_3_docx/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_4.docx/838262_supplementary-materials_datasheets_4_docx/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_5.xlsx/838262_supplementary-materials_datasheets_5_xlsx/1?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Data_Sheet_6.docx/838262_supplementary-materials_datasheets_6_docx/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Image_1.pdf/838262_supplementary-materials_images_1_pdf/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Image_2.pdf/838262_supplementary-materials_images_2_pdf/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Image_3.pdf/838262_supplementary-materials_images_3_pdf/2?isPublishedV2=false
https://www.frontiersin.org/api/v3/articles/838262/file/Image_4.pdf/838262_supplementary-materials_images_4_pdf/2?isPublishedV2=false
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Anatomie und Zellbiologie
Professur: M - Prof. Dr. Gabriela Krasteva-Christ
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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