Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
doi:10.22028/D291-42235
Titel: | Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness |
VerfasserIn: | Levental, Kandice R. Malmberg, Eric Symons, Jessica L. Fan, Yang-Yi Chapkin, Robert S. Ernst, Robert Levental, Ilya |
Sprache: | Englisch |
Titel: | Nature Communications |
Bandnummer: | 11 |
Heft: | 1 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2020 |
Freie Schlagwörter: | Biophysical chemistry Cell biology Lipidomics Lipids Membrane biophysics |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Proper membrane physiology requires maintenance of biophysical properties, which must be buffered from external perturbations. While homeostatic adaptation of membrane fluidity to temperature variation is a ubiquitous feature of ectothermic organisms, such responsive membrane adaptation to external inputs has not been directly observed in mammals. Here, we report that challenging mammalian membranes by dietary lipids leads to robust lipidomic remodeling to preserve membrane physical properties. Specifically, exogenous polyunsaturated fatty acids are rapidly incorporated into membrane lipids, inducing a reduction in membrane packing. These effects are rapidly compensated both in culture and in vivo by lipidome-wide remodeling, most notably upregulation of saturated lipids and cholesterol, resulting in recovery of membrane packing and permeability. Abrogation of this response results in cytotoxicity when membrane homeostasis is challenged by dietary lipids. These results reveal an essential mammalian mechanism for membrane homeostasis wherein lipidome remodeling in response to dietary lipid inputs preserves functional membrane phenotypes. |
DOI der Erstveröffentlichung: | 10.1038/s41467-020-15203-1 |
URL der Erstveröffentlichung: | https://doi.org/10.1038/s41467-020-15203-1 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-422352 hdl:20.500.11880/37920 http://dx.doi.org/10.22028/D291-42235 |
ISSN: | 2041-1723 |
Datum des Eintrags: | 21-Jun-2024 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-15203-1/MediaObjects/41467_2020_15203_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-15203-1/MediaObjects/41467_2020_15203_MOESM2_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-15203-1/MediaObjects/41467_2020_15203_MOESM3_ESM.xlsx https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-15203-1/MediaObjects/41467_2020_15203_MOESM4_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-15203-1/MediaObjects/41467_2020_15203_MOESM5_ESM.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biochemie und Molekularbiologie |
Professur: | M - Prof. Dr. Robert Ernst |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
s41467-020-15203-1.pdf | 1,27 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons