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doi:10.22028/D291-41668
Title: | Reprint of The effect of N-acetylcysteine and working memory training on cocaine use, craving and inhibition in regular cocaine users: correspondence of lab assessments and Ecological Momentary Assessment |
Author(s): | Schulte, Mieke H. J. Wiers, Reinout W. Boendermaker, Wouter J. Goudriaan, Anna E. van den Brink, Wim van Deursen, Denise S. Friese, Malte Brede, Emily Waters, Andrew J. |
Language: | English |
Title: | Addictive Behaviors |
Volume: | 83 |
Pages: | 79-86 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2018 |
Free key words: | Cocaine Craving Inhibition N-acetylcysteine Working memory training Ecological momentary assessment |
DDC notations: | 150 Psychology |
Publikation type: | Journal Article |
Abstract: | Introduction: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data. Methods: Twenty-four of 38 cocaine-using men completed a 25-day intervention with 2400 mg/day NAC or placebo and WM-training as well as two lab-visits assessing cocaine use, craving and inhibition (Stop Signal task). Additionally, cocaine use, craving and cognition (Stroop task) were assessed using EMA during treatment, with 26 participants completing 819 assessments. Results: Cocaine problems according to the Drug Use Disorder Identification Test (DUDIT) decreased more after NAC than after placebo, and the proportion of cocaine-positive urines at lab-visit 2 was lower in the NAC group. No NAC effects were found on craving. For cocaine use and craving, results from the lab data were generally similar to EMA results. NAC also showed some effects on cognitive control: improved inhibition assessed with the Stop Signal task in the lab, and decreased classic Stroop performance during EMA. There were no significant effects of number of completed WM-training sessions. Conclusions: Overall this study revealed mixed findings regarding the treatment of cocaine use disorders with NAC and WM-training. The effect of NAC on inhibition should be further investigated. |
DOI of the first publication: | 10.1016/j.addbeh.2018.03.023 |
URL of the first publication: | https://doi.org/10.1016/j.addbeh.2018.03.023 |
Link to this record: | urn:nbn:de:bsz:291--ds-416686 hdl:20.500.11880/37307 http://dx.doi.org/10.22028/D291-41668 |
ISSN: | 0306-4603 |
Date of registration: | 23-Feb-2024 |
Faculty: | HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft |
Department: | HW - Psychologie |
Professorship: | HW - Prof. Dr. Malte Friese |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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