Please use this identifier to cite or link to this item: doi:10.22028/D291-41668
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Title: Reprint of The effect of N-acetylcysteine and working memory training on cocaine use, craving and inhibition in regular cocaine users: correspondence of lab assessments and Ecological Momentary Assessment
Author(s): Schulte, Mieke H. J.
Wiers, Reinout W.
Boendermaker, Wouter J.
Goudriaan, Anna E.
van den Brink, Wim
van Deursen, Denise S.
Friese, Malte
Brede, Emily
Waters, Andrew J.
Language: English
Title: Addictive Behaviors
Volume: 83
Pages: 79-86
Publisher/Platform: Elsevier
Year of Publication: 2018
Free key words: Cocaine
Craving
Inhibition
N-acetylcysteine
Working memory training
Ecological momentary assessment
DDC notations: 150 Psychology
Publikation type: Journal Article
Abstract: Introduction: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data. Methods: Twenty-four of 38 cocaine-using men completed a 25-day intervention with 2400 mg/day NAC or placebo and WM-training as well as two lab-visits assessing cocaine use, craving and inhibition (Stop Signal task). Additionally, cocaine use, craving and cognition (Stroop task) were assessed using EMA during treatment, with 26 participants completing 819 assessments. Results: Cocaine problems according to the Drug Use Disorder Identification Test (DUDIT) decreased more after NAC than after placebo, and the proportion of cocaine-positive urines at lab-visit 2 was lower in the NAC group. No NAC effects were found on craving. For cocaine use and craving, results from the lab data were generally similar to EMA results. NAC also showed some effects on cognitive control: improved inhibition assessed with the Stop Signal task in the lab, and decreased classic Stroop performance during EMA. There were no significant effects of number of completed WM-training sessions. Conclusions: Overall this study revealed mixed findings regarding the treatment of cocaine use disorders with NAC and WM-training. The effect of NAC on inhibition should be further investigated.
DOI of the first publication: 10.1016/j.addbeh.2018.03.023
URL of the first publication: https://doi.org/10.1016/j.addbeh.2018.03.023
Link to this record: urn:nbn:de:bsz:291--ds-416686
hdl:20.500.11880/37307
http://dx.doi.org/10.22028/D291-41668
ISSN: 0306-4603
Date of registration: 23-Feb-2024
Faculty: HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft
Department: HW - Psychologie
Professorship: HW - Prof. Dr. Malte Friese
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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