Please use this identifier to cite or link to this item: doi:10.22028/D291-41513
Title: Dkk1 as a Prognostic Marker for Neoadjuvant Chemotherapy Response in Breast Cancer Patients
Author(s): Kasoha, Mariz
Steinbach, Anna K.
Bohle, Rainer M.
Linxweiler, Barbara
Haj Hamoud, Bashar
Doerk, Merle
Nigdelis, Meletios P.
Stotz, Lisa
Zimmermann, Julia S. M.
Solomayer, Erich-Franz
Kaya, Askin C.
Radosa, Julia C.
Language: English
Title: Cancers
Volume: 16
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2024
Free key words: breast cancer
neoadjuvant therapy
therapy response
personalised treatment
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Purpose: To investigate the role of Dkk1 as a predictor of response to NACT in BC patients. Methods: This retrospective monocentric study included 145 women who had undergone NACT followed by breast surgery. Dkk1 protein expression was assessed using immunohistochemistry staining in core needle biopsies and mammary carcinoma specimens. Results: Dkk1 levels were lower in treated BC tumours than in untreated tumours. The outcomes of 68 matched pre- and post-therapy tissues showed that Dkk1 levels in mammary carcinoma tissues were significantly predicted by levels in core needle biopsies and that Dkk1 expression was reduced in 83% of cases. Smaller cT stage, positive Her2 expression, and decreased Dkk1-IRS in core needle biopsy tissues were all independent predictors of regression grade (R4), according to Sinn. However, the percentage of Dkk1 expression differences prior to and following NACT had no effect on PFS or OS. Conclusions: In this study, we demonstrated for the first time that Dkk1 could be identified as an independent predictor of NACT response in BC patients, particularly those with TNBC. Further research with a multicentric expanded (pre-/post-therapy) sample set and better-defined populations in terms of molecular subtypes, therapy modality, and long-term follow-up is recommended to obtain more solid evidence.
DOI of the first publication: 10.3390/cancers16020419
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-415134
ISSN: 2072-6694
Date of registration: 8-Feb-2024
Description of the related object: Supplementary Materials
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
M - Pathologie
Professorship: M - Prof. Dr. Rainer M. Bohle
M - Prof. Dr. E.-F. Solomayer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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