Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-41473
Titel: | Eosinophilic Esophagitis on and off Proton Pump Inhibitor |
Alternativtitel: | Esofagite eosinofílica com e sem inibidor da bomba de protões |
VerfasserIn: | Zimmer, Vincent Emrich, Kai |
Sprache: | Englisch |
Titel: | GE Portuguese Journal of Gastroenterology |
Bandnummer: | 30 |
Heft: | Suppl 2 |
Seiten: | 62-65 |
Verlag/Plattform: | Karger |
Erscheinungsjahr: | 2023 |
Freie Schlagwörter: | Esophageal stricture Dysphagia Diagnostic esophagogastro-duodenoscopy Proton pump inhibitor Eosinophilic esophagitis Estenose esofágica Disfagia Endoscopia diagnóstica Inibidor da bomba de protões Esofagite eosinofílica |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Pre-endoscopy empirical PPI usage has become standard in many countries, albeit there are significant concerns in terms of masking relevant endoscopy findings, which may, among others, include eosinophilic esophagitis (EoE), thus clearly calling for a change in practice pattern [1, 2]. A 28-year-old male patient with birch pollen allergy and dysphagia for solids and reflux-like symptoms for several months with incomplete response to proton pump inhibitors (PPIs) was referred for endoscopic stricture treatment due to a presumed reflux-related stricture. Outside office-based index esophago-gastro-duodenoscopy (EGD), while on empiric standard-dose PPI treatment, indicated a small hiatal hernia along with a discrete short stricture. At the time, biopsies from the distal esophagus remained noncontributory. The recent EGD indicated questionable linear furrows with minor reduction in submucosal vessel visibility in the proximal esophagus (Fig. 1a). The short distal stricture was well reproduced (Fig. 1b), and a bougienage up to 20 mm using Savary-Gilliard bougies was performed (Fig. 1c; note fully preserved vascular markings in the distal esophagus). Given the lack of relevant mucosal tears after maximal bougienage (Fig. 1d), an additional radial electroincision using an IT knife was conducted (not shown). Esophageal biopsies with an adequate biopsy protocol (> two heights, >6 biopsies) yielded no evidence for potentially underlying EoE. Since the patient only benefitted transiently from the procedure and presented again after only 2 weeks with reflux-like symptoms and dysphagia, ancillary esophageal manometry did not demonstrate dysmotility. The patient consented to withdraw PPI treatment for 2 weeks with alginate bridging, causing significant clinical deterioration, i.e. worsening reflux and dysphagia. Repeat EGD provided clear-cut endoscopic EoE evidence with diffuse furrowing, diffuse lack of submucosal vessels reflecting significant edema (Fig. 2a) as well as recurrence of the distal stricture (Fig. 2b). In addition, coarse exudates were noted at the level of linear furrows, which were specifically targeted for histopathology [3, 4] (Fig. 2c – EREFS score 5). Repeat biopsies off PPI confirmed presence of EoE in this patient with a maximum infiltration of >32/HPF in the proximal esophagus. The patient was successfully treated by 2 × 1 mg orodispersible budesonide. |
DOI der Erstveröffentlichung: | 10.1159/000529548 |
URL der Erstveröffentlichung: | https://doi.org/10.1159/000529548 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-414734 hdl:20.500.11880/37156 http://dx.doi.org/10.22028/D291-41473 |
ISSN: | 2341-4545 |
Datum des Eintrags: | 22-Jan-2024 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons