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Titel: Imbalanced Folate and Vitamin B12 in the Third Trimester of Pregnancy and its Association with Birthweight and Child Growth up to 2 Years
VerfasserIn: Obeid, Rima
Eussen, Simone J. P. M.
Mommers, Monique
Smits, Luc
Thijs, Carel
Sprache: Englisch
In:
Titel: Molecular Nutrition & Food Research
Bandnummer: 66 (2022)
Heft: 2
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: birthweight
child growth
folate trap
imbalanced folate and vitamin B12
pregnancy
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Scope: Folic acid supplementation during pregnancy may lead to an imbalance when vitamin B12 intake is low (folate trap) and may affect child’s growth. Methods: The authors study the association between third trimester maternal intakes of folate and B12 and birthweight and postnatal growth of 2632 infants from the KOALA Birth Cohort Study. Plasma vitamin biomarkers are measured in 1219 women. Results: Imbalanced total intakes (folate > 430 µg day−1 combined with B12 < 5.5 µg day−1) are not associated with birthweight [𝜷 adj (95% CI) = –14.87 (–68.87, 39.13)] compared with high intakes of both. Imbalanced intake is associated with a lower z score of weight at 1–2 years [𝜷 adj = –0.14 (–0.25, –0.03)]. Having red blood cell folate > 745 nmol L−1 and plasma B12 < 172 pmol L−1 is not associated with birthweight [𝜷 adj = –7.10 (–97.90, 83.71) g]. Maternal dietary B12 intake [𝜷 adj = –9.5 (–15.6, –3.3)] and plasma methylmalonic acid [𝜷 adj = 234 (43, 426)] are associated with birthweight. Conclusion: Low maternal dietary B12 intake and elevated methylmalonic acid rather than imbalanced vitamins are associated with higher birthweight, suggesting that low maternal B12 can predispose the infants for later obesity.
DOI der Erstveröffentlichung: 10.1002/mnfr.202100662
URL der Erstveröffentlichung: https://doi.org/10.1002/mnfr.202100662
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-411442
hdl:20.500.11880/36928
http://dx.doi.org/10.22028/D291-41144
ISSN: 1613-4133
1613-4125
Datum des Eintrags: 22-Nov-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons