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doi:10.22028/D291-41144
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Molecular Nutrition Food Res - 2021 - Obeid - Imbalanced Folate and Vitamin B12 in the Third Trimester of Pregnancy and its.pdf | 390,54 kB | Adobe PDF | Öffnen/Anzeigen |
Titel: | Imbalanced Folate and Vitamin B12 in the Third Trimester of Pregnancy and its Association with Birthweight and Child Growth up to 2 Years |
VerfasserIn: | Obeid, Rima Eussen, Simone J. P. M. Mommers, Monique Smits, Luc Thijs, Carel |
Sprache: | Englisch |
In: | |
Titel: | Molecular Nutrition & Food Research |
Bandnummer: | 66 (2022) |
Heft: | 2 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | birthweight child growth folate trap imbalanced folate and vitamin B12 pregnancy |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Scope: Folic acid supplementation during pregnancy may lead to an imbalance when vitamin B12 intake is low (folate trap) and may affect child’s growth. Methods: The authors study the association between third trimester maternal intakes of folate and B12 and birthweight and postnatal growth of 2632 infants from the KOALA Birth Cohort Study. Plasma vitamin biomarkers are measured in 1219 women. Results: Imbalanced total intakes (folate > 430 µg day−1 combined with B12 < 5.5 µg day−1) are not associated with birthweight [𝜷 adj (95% CI) = –14.87 (–68.87, 39.13)] compared with high intakes of both. Imbalanced intake is associated with a lower z score of weight at 1–2 years [𝜷 adj = –0.14 (–0.25, –0.03)]. Having red blood cell folate > 745 nmol L−1 and plasma B12 < 172 pmol L−1 is not associated with birthweight [𝜷 adj = –7.10 (–97.90, 83.71) g]. Maternal dietary B12 intake [𝜷 adj = –9.5 (–15.6, –3.3)] and plasma methylmalonic acid [𝜷 adj = 234 (43, 426)] are associated with birthweight. Conclusion: Low maternal dietary B12 intake and elevated methylmalonic acid rather than imbalanced vitamins are associated with higher birthweight, suggesting that low maternal B12 can predispose the infants for later obesity. |
DOI der Erstveröffentlichung: | 10.1002/mnfr.202100662 |
URL der Erstveröffentlichung: | https://doi.org/10.1002/mnfr.202100662 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-411442 hdl:20.500.11880/36928 http://dx.doi.org/10.22028/D291-41144 |
ISSN: | 1613-4133 1613-4125 |
Datum des Eintrags: | 22-Nov-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons