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doi:10.22028/D291-41141
Titel: | Elevated seminal protein carbonyl concentration is correlated with asthenozoospermia and affects adversely the laboratory intracytoplasmic sperm injection (ICSI) outcomes |
VerfasserIn: | Al Smadi, Mohammad A. Hammadeh, Mohamad Eid Batiha, Osamah Al Sharu, Emad Altalib, Mohammad M. Jahmani, Mohammad Y. Mahdy, Ahmed Amor, Houda |
Sprache: | Englisch |
Titel: | Andrologia |
Bandnummer: | 53 |
Heft: | 11 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | embryo quality score fertilisation rate protein carbonyl sperm motility |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Elevated concentrations of reactive oxygen species (ROS) in the semen can lead to oxidative protein damage as they react with the amino acids' side chains in the protein, leading to the generation of carbonyl groups. This study aimed to investigate the effect of protein carbonyl (PC) concentration on sperm motility and the laboratory intracytoplasmic sperm injection (ICSI) outcomes. A total of 150 couples from the ICSI cycle were enrolled in this study and were divided into three groups (G) according to the PC concentration as following, G1 included samples with PC concentrations <0.65 nmol/mg, G2 included samples with 0.65≤PC≤2.23 nmol/mg and G3 included samples with PC>2.23 (nmol/mg). PC concentrations were measured in all semen samples, and the laboratory ICSI outcomes were evaluated for all injected oocytes. The Kruskal–Wallis p-values for the differences in the medians of sperm motility, fertilisation rate, embryo cleavage score and embryo quality score were <0.05. Furthermore, Dunn's post hoc test showed a significant difference between all groups, p-values <0.05, except for the medians of embryo quality score between G2 and G3. In conclusion, our results showed that sperm motility and laboratory ICSI outcomes are affected negatively by higher concentrations of PC in the semen. |
DOI der Erstveröffentlichung: | 10.1111/and.14232 |
URL der Erstveröffentlichung: | https://doi.org/10.1111/and.14232 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-411417 hdl:20.500.11880/36926 http://dx.doi.org/10.22028/D291-41141 |
ISSN: | 1439-0272 0303-4569 |
Datum des Eintrags: | 22-Nov-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Frauenheilkunde M - Innere Medizin |
Professur: | M - Prof. Dr. Robert Bals M - Prof. Dr. E.-F. Solomayer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Andrologia - 2021 - Al Smadi - Elevated seminal protein carbonyl concentration is correlated with asthenozoospermia and.pdf | 727,54 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons