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Titel: Elevated seminal protein carbonyl concentration is correlated with asthenozoospermia and affects adversely the laboratory intracytoplasmic sperm injection (ICSI) outcomes
VerfasserIn: Al Smadi, Mohammad A.
Hammadeh, Mohamad Eid
Batiha, Osamah
Al Sharu, Emad
Altalib, Mohammad M.
Jahmani, Mohammad Y.
Mahdy, Ahmed
Amor, Houda
Sprache: Englisch
Titel: Andrologia
Bandnummer: 53
Heft: 11
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: embryo quality score
fertilisation rate
protein carbonyl
sperm motility
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Elevated concentrations of reactive oxygen species (ROS) in the semen can lead to oxidative protein damage as they react with the amino acids' side chains in the protein, leading to the generation of carbonyl groups. This study aimed to investigate the effect of protein carbonyl (PC) concentration on sperm motility and the laboratory intracytoplasmic sperm injection (ICSI) outcomes. A total of 150 couples from the ICSI cycle were enrolled in this study and were divided into three groups (G) according to the PC concentration as following, G1 included samples with PC concentrations <0.65 nmol/mg, G2 included samples with 0.65≤PC≤2.23 nmol/mg and G3 included samples with PC>2.23 (nmol/mg). PC concentrations were measured in all semen samples, and the laboratory ICSI outcomes were evaluated for all injected oocytes. The Kruskal–Wallis p-values for the differences in the medians of sperm motility, fertilisation rate, embryo cleavage score and embryo quality score were <0.05. Furthermore, Dunn's post hoc test showed a significant difference between all groups, p-values <0.05, except for the medians of embryo quality score between G2 and G3. In conclusion, our results showed that sperm motility and laboratory ICSI outcomes are affected negatively by higher concentrations of PC in the semen.
DOI der Erstveröffentlichung: 10.1111/and.14232
URL der Erstveröffentlichung: https://doi.org/10.1111/and.14232
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-411417
hdl:20.500.11880/36926
http://dx.doi.org/10.22028/D291-41141
ISSN: 1439-0272
0303-4569
Datum des Eintrags: 22-Nov-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Frauenheilkunde
M - Innere Medizin
Professur: M - Prof. Dr. Robert Bals
M - Prof. Dr. E.-F. Solomayer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons