Please use this identifier to cite or link to this item: doi:10.22028/D291-41121
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Title: Serum titers of autoantibodies against α-synuclein and tau in child- and adulthood
Author(s): Kuhn, Isabell
Rogosch, Tobias
Schindler, Theresa I.
Tackenberg, Björn
Zemlin, Michael
Maier, Rolf F.
Dodel, Richard
Kronimus, Yannick
Language: English
Title: Journal of Neuroimmunology
Volume: 315 (2018)
Pages: 33-39
Publisher/Platform: Elsevier
Year of Publication: 2017
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Autoreactive antibodies against the proteins alpha-synuclein (α-syn) and tau are detectable in body fluids of both healthy and diseased elderly people. However, nothing is known about their presence or titers in children. To close this gap and to characterize their temporary expression levels, we used ELISA techniques to investigate the serum titers of α-syn and tau reactive autoantibodies in 37 and 32 adults and 37 and 31 children, respectively. Most serum samples from the children exhibited both antibody types and interestingly, the levels were similar to those observed in the adult serum samples. Furthermore, sex-specific analysis revealed significantly increased α-syn reactive autoantibody titers in female children. The presence of α-syn and tau reactive autoantibodies in early childhood indicates that both immunoglobulins belong to the pool of naturally occurring autoantibodies (nAbs), as their antigen-independent synthesis from birth is a crucial characteristic. Due to their general participation in the maintenance of the physiological homeostasis, we hypothesize that both investigated nAbs are involved in the metabolic regulation of their specific antigen. Therefore, they may be a part of a mechanism that already exists in the innate immunological repertoire to provide protection from pathologies caused by dysregulated α-syn and tau metabolisms.
DOI of the first publication: 10.1016/j.jneuroim.2017.12.003
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-411219
ISSN: 0165-5728
Date of registration: 20-Nov-2023
Description of the related object: Supplementary data
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Pädiatrie
Professorship: M - Prof. Dr. Michael Zemlin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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