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doi:10.22028/D291-41062
Titel: | Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004 |
VerfasserIn: | Rasche, M. von Neuhoff, C. Dworzak, M. Bourquin, J.-P. Bradtke, J. Göhring, G. Escherich, G. Fleischhack, G. Graf, N. Gruhn, B. Haas, O. A. Klingebiel, T. Kremens, B. Lehrnbecher, T. von Stackelberg, A. Tchinda, J. Zemanova, Z. Thiede, C. von Neuhoff, N. Zimmermann, M. Creutzig, U. Reinhardt, D. |
Sprache: | Englisch |
Titel: | Leukemia |
Bandnummer: | 31 |
Heft: | 12 |
Seiten: | 2807-2814 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2017 |
Freie Schlagwörter: | Acute myeloid leukaemia Cancer Cancer genetics Cytogenetics Genetics research Paediatric cancer Prognostic markers |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-BerlinFrankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+ ), complex (CK+ ) and hypodiploid (HK+ ) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK+ (n = 22) as a new independent risk factor for poor event-free survival (EFS 23 ± 9% vs 53 ± 2% for all other patients, P = 0.0003), even after exclusion of four patients with monosomy 7 (EFS 28 ± 11%, P = 0.0081). CK+ patients without MK had a better prognosis (n = 47, EFS 47 ± 8%, P = 0.46) than those with MK+ (n = 12, EFS 25 ± 13%, P = 0.024). HK+ (n = 37, EFS 44 ± 8% for total cohort, P = 0.3) influenced outcome only when t(8;21) patients were excluded (remaining n = 16, EFS 9 ± 8%, Po0.0001). An extremely poor outcome was observed for MK+ /HK+ patients (n = 10, EFS 10 ± 10%, Po0.0001). Finally, isolated trisomy 8 was also associated with low EFS (n = 16, EFS 25 ± 11%, P = 0.0091). In conclusion, monosomal karyotype is a strong and independent predictor for high-risk pediatric AML. In addition, isolated trisomy 8 and hypodiploidy without t(8;21) coincide with dismal outcome. These results have important implications for risk stratification and should be further validated in independent pediatric cohorts. |
DOI der Erstveröffentlichung: | 10.1038/leu.2017.121 |
URL der Erstveröffentlichung: | https://doi.org/10.1038/leu.2017.121 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-410627 hdl:20.500.11880/36851 http://dx.doi.org/10.22028/D291-41062 |
ISSN: | 1476-5551 0887-6924 |
Datum des Eintrags: | 13-Nov-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1038%2Fleu.2017.121/MediaObjects/41375_2017_BFleu2017121_MOESM128_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Pädiatrie |
Professur: | M - Prof. Dr. Norbert Graf |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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leu2017121.pdf | 1,12 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons