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Titel: Risk Factors and Main Indications for Palivizumab Prophylaxis in a Second Season Population: Results From the German Synagis Registry 2009-2016
VerfasserIn: Simon, Arne
Gehrmann, Susanne
Wagenpfeil, Gudrun
Wagenpfeil, Stefan
Sprache: Englisch
Titel: The Pediatric infectious disease journal
Bandnummer: 37
Heft: 10
Seiten: 987-991
Verlag/Plattform: Wolters Kluwer
Erscheinungsjahr: 2018
Freie Schlagwörter: respiratory syncytial virus
palivizumab
second season
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: After national recommendations, palivizumab is administered in Germany to high-risk infants to prevent hospitalizations related to respiratory syncytial virus (RSV) infection. Limited data are available to characterize those children who receive palivizumab in 2 consecutive RSV seasons. Methods: This was a comparative analysis of data from a postmarketing observational study (German SYNAGIS Registry, AbbVie Germany GmbH & Co.KG, Wiesbaden) detailing RSV-related risk factors and main indications for palivizumab in 920 children who received at ≥1 palivizumab injection in a second season between 2010 and 2016 [second season population (SSP)]. Results: Median birth weight and gestational age at birth as well as the proportion of children with hemodynamically significant congenital heart disease, with any form of chronic lung disease of prematurity or with any form of neuromuscular impairment, were significantly higher in the SSP. Accordingly, hemodynamically significant congenital heart disease, chronic lung disease and other reasons (including neuromuscular impairment) and not prematurity were the main indications for palivizumab in the SSP. The RSV-related hospitalization rate confirmed by viral testing in the SSP (receiving palivizumab prophylaxis) was 0.9%. No deaths due to RSV were reported. Conclusions: Second season recipients of palivizumab differ from one season recipients of palivizumab in terms of risk factors and main indications for prophylaxis. Keeping in mind the limitations of an uncontrolled prospective observational study, these results support the effectiveness of palivizumab (concerning the RSV rehospitalization rate) and do not reveal new safety alerts in a large SSP.
DOI der Erstveröffentlichung: 10.1097/INF.0000000000002133
URL der Erstveröffentlichung: https://journals.lww.com/pidj/fulltext/2018/10000/risk_factors_and_main_indications_for_palivizumab.6.aspx
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-406750
hdl:20.500.11880/36561
http://dx.doi.org/10.22028/D291-40675
ISSN: 0891-3668
Datum des Eintrags: 4-Okt-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professur: M - Prof. Dr. Stefan Wagenpfeil
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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