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doi:10.22028/D291-40674
Titel: | Palivizumab use in infants with Down syndrome-report from the German Synagis™ Registry 2009-2016 |
VerfasserIn: | Simon, Arne Gehrmann, Susanne Wagenpfeil, Gudrun Wagenpfeil, Stefan |
Sprache: | Englisch |
Titel: | European journal of pediatrics |
Bandnummer: | 177 |
Heft: | 6 |
Seiten: | 903–911 |
Verlag/Plattform: | Springer |
Erscheinungsjahr: | 2018 |
Freie Schlagwörter: | Down syndrome Respiratory syncytial virus Palivizumab prophylaxis RSV-related hospitalization Bronchiolitis |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Infants with Down syndrome (DS) face an increased risk of respiratory tract infections. Recent studies describe DS as independent risk factor for a complicated clinical course in infants with respiratory syncytial virus (RSV) infection. The prospective observational German Synagis™ Registry comprises data from 249 children below 25 months of age with DS and palivizumab prophylaxis 2009–2016 (1191 administrations; mean 4.8 per patient and season). The median gestational age and the birth weight in patients without and with DS were 31 versus 37 weeks (P < 0.001) and 1590 versus 2750 g, respectively (P < 0.001). Patients with DS significantly more often had congenital heart disease (CHD), siblings in kindergarten or school, treatment with oxygen at home, immunodeficiency, and neuromuscular impairment. The RSV-related hospitalization rate in patients with DS was 1.20%; the hospitalization rate in patients without DS was 0.71%. Conclusion: Data from 249 children with DS receiving palivizumab prophylaxis in seven consecutive RSV seasons (2009–2016) in Germany reveal important differences between patients with and without DS concerning the main indication for palivizumab use and additional risk factors. Bearing in mind the limitations of an uncontrolled postmarketing observational study, the results confirm the field effectiveness of palivizumab prophylaxis in this special population. |
DOI der Erstveröffentlichung: | 10.1007/s00431-018-3142-x |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00431-018-3142-x |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-406749 hdl:20.500.11880/36560 http://dx.doi.org/10.22028/D291-40674 |
ISSN: | 0340-6199 1432-1076 |
Datum des Eintrags: | 4-Okt-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Prof. Dr. Stefan Wagenpfeil |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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