Please use this identifier to cite or link to this item: doi:10.22028/D291-40647
Title: Prognostic significance of age in 5631 patients with Wilms tumour prospectively registered in International Society of Paediatric Oncology (SIOP) 93-01 and 2001
Author(s): Hol, J. A.
Lopez-Yurda, M. I.
Van Tinteren, H.
Van Grotel, M.
Godzinski, J.
Vujanic, G.
Oldenburger, F.
De Camargo, B.
Ramírez-Villar, G. L.
Bergeron, C.
Pritchard-Jones, K.
Graf, N.
Van den Heuvel-Eibrink, M. M.
Language: English
Title: PloS One
Volume: 14
Issue: 8
Publisher/Platform: Plos
Year of Publication: 2019
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background To enhance risk stratification for Wilms tumour (WT) in a pre-operative chemotherapy setting, we explored the prognostic significance and optimal age cutoffs in patients treated according to International Society of Paediatric Oncology Renal Tumour Study Group (SIOP-RTSG) protocols. Methods Patients(6 months-18 years) with unilateral WT were selected from prospective SIOP 93– 01 and 2001 studies(1993–2016). Martingale residual analysis was used to explore optimal age cutoffs. Outcome according to age was analyzed by uni- and multivariable analysis, adjusted for sex, biopsy(yes/no), stage, histology and tumour volume at surgery. Results 5631 patients were included; median age was 3.4 years(IQR: 2–5.1). Estimated 5-year event-free survival (EFS) and overall survival (OS) were 85%(95%CI 83.5–85.5) and 93% (95%CI 92.0–93.4). Martingale residual plots detected no optimal age cutoffs. Multivariable analysis showed lower EFS with increasing age(linear trend P<0.001). Using previously described age categories, EFS was lower for patients aged 2-4(HR 1.34, P = 0.02), 4-10 (HR 1.83, P<0.0001) and 10–18 years(HR 1.74, P = 0.01) as compared to patients aged 6 months-2 years. OS was lower for patients 4–10 years(HR 1.67, P = 0.01) and 10–18 years (HR 1.87, P = 0.04), but not for 2–4 years(HR 1.29, P = 0.23). Higher stage, histological risk group and tumour volume were independent adverse prognostic factors. Conclusion Although optimal age cutoffs could not be identified, we demonstrated the prognostic significance of age as well as previously described cutoffs for EFS (2 and 4 years) and OS (4 years) in children with WT treated with pre-operative chemotherapy. These findings encourage the consideration of age in the design of future SIOP-RTSG protocols.
DOI of the first publication: 10.1371/journal.pone.0221373
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-406474
ISSN: 1932-6203
Date of registration: 28-Sep-2023
Description of the related object: Supporting information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Pädiatrie
Professorship: M - Prof. Dr. Norbert Graf
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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