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Titel: Early deaths from childhood cancer in Germany 1980-2016
VerfasserIn: Becker, Cornelia
Graf, Norbert
Grabow, Desiree
Creutzig, Ursula
Reinhardt, Dirk
Weyer-Elberich, Veronika
Spix, Claudia
Kaatsch, Peter
Sprache: Englisch
Titel: Cancer Epidemiology
Bandnummer: 65
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2020
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background Even though the survival of childhood cancer has improved over the last decades, there are still children dying shortly after diagnosis. The aim of the study is to add to understanding of the reasons for deaths shortly after date of diagnosis. Methods Using data of the population-based German Childhood Cancer Registry (cancer below 15 years of age diagnosed between 1980 and 2016), we compared characteristics of 671 children with cancer who died within 30 days of diagnosis to 53,649 patients with childhood cancer who survived longer. In addition to a descriptive analysis, we used logistic regression with multivariable fractional polynomials to describe the relationship between early death with age at diagnosis and year of diagnosis. Results The number of early death cases and the risk of early death have decreased considerably since 1980 (2.6% of study population in 1980-89 to 0.6% in 2010-16). Children under one year of age were at highest early death risk (odds ratio = 4.10, 95% confidence interval: 3.32–5.05 compared to 7-year-old patients). These results are similar to results from other studies. Moreover, children with acute myeloid leukemia and hepatic tumors had a higher early death risk, children with acute lymphoid leukemia a lower risk compared to patients with central nervous system tumors used as a reference group. Conclusion Even though the risk for early death has declined overall with advances in diagnosis and therapy, special attention needs to be paid to infants and children with AML and hepatic tumors, who are especially at risk.
DOI der Erstveröffentlichung: 10.1016/j.canep.2020.101669
URL der Erstveröffentlichung: https://doi.org/10.1016/j.canep.2020.101669
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-406378
hdl:20.500.11880/36509
http://dx.doi.org/10.22028/D291-40637
ISSN: 1877-7821
Datum des Eintrags: 28-Sep-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Norbert Graf
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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