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Titel: Diffusion-weighted MRI and histogram analysis: assessment of response to neoadjuvant chemotherapy in nephroblastoma
VerfasserIn: Hötker, Andreas M.
Mazaheri, Yousef
Lollert, André
Schenk, Jens-Peter
Zheng, Junting
Capanu, Marinela
Akin, Oguz
Graf, Norbert
Staatz, Gundula
Sprache: Englisch
Titel: Abdominal Radiology
Bandnummer: 46
Heft: 7
Seiten: 3317-3325
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2021
Freie Schlagwörter: Nephroblastoma
Magnetic resonance imaging
Diffusion-weighted imaging
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Purpose To assess the value of difusion-weighted MRI (DW-MRI) in the non-invasive prediction of blastemal remnant after neoadjuvant chemotherapy in nephroblastoma. Methods This IRB-approved study included 32 pediatric patients with 35 tumors who underwent DW-MRI prior and after completion of neoadjuvant chemotherapy and subsequent surgical resection. Two blinded radiologists volumetrically assessed each tumor on pre- and post-neoadjuvant images and the parameters mean ADC, median ADC, 12.5th/25th/75th ADC percentile, skewness, and kurtosis were calculated. Blastemal remnant was determined per the pathology report. Associations between imaging features and blastemal remnant quartiles were examined using the Kruskal–Wallis test and adjusted for false discovery rate. Results Inter-reader agreement was high for mean ADC, skewness, kurtosis, and volume (ICC: 0.76–0.998). Pre-therapeutic histogram parameters skewness and kurtosis were found to be higher in patients with a higher amount of blastemal remnant for reader 1 (overall p=0.035) and for kurtosis in reader 2 (overall p=0.032) with skewness not reaching the level of statistical signifcance (overall p=0.055). Higher tumor volume on pre-treatment imaging was associated with a higher amount of blastemal remnant after therapy (overall p=0.032 for both readers). Conclusions Pre-treatment skewness and kurtosis of ADC histogram analysis were signifcantly associated with a larger fraction of a blastemal remnant after neoadjuvant chemotherapy. These fndings could be incorporated into a more personalized chemotherapeutic regime in these patients and ofer prognostic information at the time of initial diagnosis.
DOI der Erstveröffentlichung: 10.1007/s00261-021-03032-9
URL der Erstveröffentlichung: https://link.springer.com/article/10.1007/s00261-021-03032-9
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-406126
hdl:20.500.11880/36491
http://dx.doi.org/10.22028/D291-40612
ISSN: 2366-0058
2366-004X
Datum des Eintrags: 27-Sep-2023
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Information
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1007%2Fs00261-021-03032-9/MediaObjects/261_2021_3032_MOESM1_ESM.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Norbert Graf
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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