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Titel: MRI Characteristics of Pediatric Renal Tumors: A SIOP-RTSG Radiology Panel Delphi Study
VerfasserIn: van der Beek, Justine N.
Watson, Tom A.
Nievelstein, Rutger A. J.
Brisse, Hervé J.
Morosi, Carlo
Lederman, Henrique M.
Coma, Ana
Gavra, Maria M.
Vult von Steyern, Kristina
Lakatos, Karoly
Breysem, Luc
Varga, Edit
Ducou Le Pointe, Hubert
Lequin, Maarten H.
Schäfer, Jürgen F.
Mentzel, Hans-Joachim
Hötker, Andreas M.
Calareso, Giuseppina
Swinson, Sophie
Kyncl, Martin
Granata, Claudio
Aertsen, Michael
Di Paolo, Pier Luigi
de Krijger, Ronald R.
Graf, Norbert
Olsen, Øystein E.
Schenk, Jens-Peter
van den Heuvel-Eibrink, Marry M
Littooij, Annemieke S.
Sprache: Englisch
Titel: Journal of Magnetic Resonance Imaging
Bandnummer: 55 (2022)
Heft: 2
Seiten: 543-552
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: renal tumor
pediatric
Wilms tumor
Delphi technique
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background The SIOP-Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis-based treatment initiation, but only for a relatively small percentage of approximately 10% of non-Wilms tumors (non-WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating characteristics. Purpose To identify MRI characteristics that may be used for discrimination of newly diagnosed pediatric renal tumors. Study Type Consensus process using a Delphi method. Population Not applicable. Field Strength/Sequence Abdominal MRI including T1- and T2-weighted imaging, contrast-enhanced MRI, and diffusion-weighted imaging at 1.5 or 3 T. Assessment Twenty-three radiologists from the SIOP-RTSG radiology panel with ≥5 years of experience in MRI of pediatric renal tumors and/or who had assessed ≥50 MRI scans of pediatric renal tumors in the past 5 years identified potentially discriminatory characteristics in the first questionnaire. These characteristics were scored in the subsequent second round, consisting of 5-point Likert scales, ranking- and multiple choice questions. Statistical Tests The cut-off value for consensus and agreement among the majority was ≥75% and ≥60%, respectively, with a median of ≥4 on the Likert scale. Results Consensus on specific characteristics mainly concerned the discrimination between WTs and non-WTs, and WTs and nephrogenic rest(s) (NR)/nephroblastomatosis. The presence of bilateral lesions (75.0%) and NR/nephroblastomatosis (65.0%) were MRI characteristics indicated as specific for the diagnosis of a WT, and 91.3% of the participants agreed that MRI is useful to distinguish NR/nephroblastomatosis from WT. Furthermore, all participants agreed that age influenced their prediction in the discrimination of pediatric renal tumors. Data Conclusion Although the discrimination of pediatric renal tumors based on MRI remains challenging, this study identified some specific characteristics for tumor subtypes, based on the shared opinion of experts. These results may guide future validation studies and innovative efforts.
DOI der Erstveröffentlichung: 10.1002/jmri.27878
URL der Erstveröffentlichung: https://doi.org/10.1002/jmri.27878
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-406110
hdl:20.500.11880/36490
http://dx.doi.org/10.22028/D291-40611
ISSN: 1522-2586
1053-1807
Datum des Eintrags: 27-Sep-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Norbert Graf
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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