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Titel: How we approach paediatric renal tumour core needle biopsy in the setting of preoperative chemotherapy: A Review from the SIOP Renal Tumour Study Group
VerfasserIn: Jackson, Thomas J.
Brisse, Herve J.
Pritchard-Jones, Kathy
Nakata, Kayo
Morosi, Carlo
Oue, Takahara
Irtan, Sabine
Vujanic, Gordan
van den Heuvel-Eibrink, Marry M.
Graf, Norbert
Chowdhury, Tanzina
Sprache: Englisch
Titel: Pediatric Blood & Cancer
Bandnummer: 69
Heft: 9
Verlag/Plattform: Wiley
Erscheinungsjahr: 2022
Freie Schlagwörter: oncology
renal tumours
Wilms tumour
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The International Society of Paediatric Oncology Renal Tumour Study Group (SIOPRTSG) advocate treating children with Wilms tumour (WT) with preoperative chemotherapy, whereas the Renal Tumor Committee of the Children’s Oncology Group (COG) advocates primary nephrectomy (without biopsy) when feasible. Successive SIOP-RTSG trial protocols recommended pretreatment biopsy of children with unilateral tumours only where there were features to suggest an increased probability of a non-WT requiring a change in management. The UK experience in the SIOP WT 2001 trial showed that an alternate approach of performing biopsies on all children with renal tumour masses to determine histology at diagnosis rarely changes management, and can result in misdiagnosis (particularly patients in the age range typical for WT). Although a more selective approach to biopsy has been routine practice in all other countries participating in SIOP-RTSG trials, there was variation between national groups. To address this variation and provide evidence-based recommendations for the indications and recommended approach to renal tumour biopsy within the SIOP paradigm, an international, multidisciplinary working group of SIOP-RTSG members was convened. We describe the resulting recommendations of this group, which are to be incorporated in the ongoing SIOP-RTSG UMBRELLA study.
DOI der Erstveröffentlichung: 10.1002/pbc.29702
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/10.1002/pbc.29702
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-405950
hdl:20.500.11880/36471
http://dx.doi.org/10.22028/D291-40595
ISSN: 1545-5017
1545-5009
Datum des Eintrags: 25-Sep-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Norbert Graf
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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