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Titel: Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers
VerfasserIn: Obeid, R
Hübner, U
Bodis, M
Gräber, Stefan
Geisel, J
Sprache: Englisch
Titel: Nutrition, metabolism, and cardiovascular diseases : NMCD
Bandnummer: 28
Heft: 4
Seiten: 411-417
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2018
Freie Schlagwörter: Aging
DNA-Methylation
Epigenetics
Supplementation
Vitamins
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background and aim: B-vitamins may influence DNA methylation. We studied the effects of vitamin D + Ca + B versus D + Ca on epigenetic age markers and biological age. Methods and results: Participants (mean ± SD of age = 68.4 ± 10.1 years) were randomized to receive 1200 IE vitamin D3 plus 800 mg Ca-carbonate alone (n = 31) or with 0.5 mg B9, 50 mg B6, and 0.5 mg B12 (n = 32). The CpG methylation of 3 genes (ASPA, ITGA2B, and PDE4C) and the changes in methylation were compared between the groups after 1 year. The changes of ASPA methylation from baseline were higher in the D + Ca + B than in the D + Ca group (1.40 ± 4.02 vs. −0.96 ± 5.12, respectively; p = 0.046, adjusted for age, sex, and baseline methylation). The changes in PDE4C from baseline were slightly higher in the D + Ca + B group (1.95 ± 3.57 vs. 0.22 ± 3.57; adjusted p = 0.062). Methylation of ITGA2B and its changes from baseline were not different between the intervention groups. Sex-adjusted odds ratio of accelerated aging (chronological age < biological age at 1 year) was 5.26 (95% confidence interval 1.51–18.28) in the D + Ca + B compared with the D + Ca group. Accelerated aging in both groups was associated with younger age. In the D + Ca + B group, it was additionally associated with lower baseline homocysteine. Conclusions: Vitamin D + Ca + B and D + Ca differentially affected epigenetic age markers, although the effect size appeared to be small after 1 year. B-vitamins effect in young subjects with low homocysteine requires further investigation. ClinicalTrials.gov ID: NCT02586181.
DOI der Erstveröffentlichung: 10.1016/j.numecd.2017.12.006
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/pii/S0939475317303204
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-405120
hdl:20.500.11880/36402
http://dx.doi.org/10.22028/D291-40512
ISSN: 0939-4753
1590-3729
Datum des Eintrags: 8-Sep-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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