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doi:10.22028/D291-40512
Titel: | Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers |
VerfasserIn: | Obeid, R Hübner, U Bodis, M Gräber, Stefan Geisel, J |
Sprache: | Englisch |
Titel: | Nutrition, metabolism, and cardiovascular diseases : NMCD |
Bandnummer: | 28 |
Heft: | 4 |
Seiten: | 411-417 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2018 |
Freie Schlagwörter: | Aging DNA-Methylation Epigenetics Supplementation Vitamins |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background and aim: B-vitamins may influence DNA methylation. We studied the effects of vitamin D + Ca + B versus D + Ca on epigenetic age markers and biological age. Methods and results: Participants (mean ± SD of age = 68.4 ± 10.1 years) were randomized to receive 1200 IE vitamin D3 plus 800 mg Ca-carbonate alone (n = 31) or with 0.5 mg B9, 50 mg B6, and 0.5 mg B12 (n = 32). The CpG methylation of 3 genes (ASPA, ITGA2B, and PDE4C) and the changes in methylation were compared between the groups after 1 year. The changes of ASPA methylation from baseline were higher in the D + Ca + B than in the D + Ca group (1.40 ± 4.02 vs. −0.96 ± 5.12, respectively; p = 0.046, adjusted for age, sex, and baseline methylation). The changes in PDE4C from baseline were slightly higher in the D + Ca + B group (1.95 ± 3.57 vs. 0.22 ± 3.57; adjusted p = 0.062). Methylation of ITGA2B and its changes from baseline were not different between the intervention groups. Sex-adjusted odds ratio of accelerated aging (chronological age < biological age at 1 year) was 5.26 (95% confidence interval 1.51–18.28) in the D + Ca + B compared with the D + Ca group. Accelerated aging in both groups was associated with younger age. In the D + Ca + B group, it was additionally associated with lower baseline homocysteine. Conclusions: Vitamin D + Ca + B and D + Ca differentially affected epigenetic age markers, although the effect size appeared to be small after 1 year. B-vitamins effect in young subjects with low homocysteine requires further investigation. ClinicalTrials.gov ID: NCT02586181. |
DOI der Erstveröffentlichung: | 10.1016/j.numecd.2017.12.006 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/pii/S0939475317303204 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-405120 hdl:20.500.11880/36402 http://dx.doi.org/10.22028/D291-40512 |
ISSN: | 0939-4753 1590-3729 |
Datum des Eintrags: | 8-Sep-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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