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doi:10.22028/D291-40509
Titel: | Rate of Cough During Treatment With Angiotensin-Converting Enzyme Inhibitors: A Meta-Analysis of Randomized Placebo-Controlled Trials |
VerfasserIn: | Vukadinović, Davor Vukadinović, Aleksandra Nikolovska Lavall, Daniel Laufs, Ulrich Wagenpfeil, Stefan Böhm, Michael |
Sprache: | Englisch |
Titel: | Clinical pharmacology and therapeutics |
Bandnummer: | 105 |
Heft: | 3 |
Seiten: | 652 - 660 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2019 |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Use of protective angiotensin-converting enzyme inhibitors (ACE-I) in patients with cardiovascular disease (CVD) is sometimes limited by incident coughing. In clinical trials, cough occurred also on placebo. We performed a meta-analysis including randomized, placebo-controlled trials reporting cough on ACE-I in patients with CVD. We evaluated the attributable fraction of cough on ACE-I accounting rate on placebo: placebo-adjusted ACE-I (%) = (ACE-I (%) - Placebo (%)) / ACE-I (%). In total, 65,054 patients from 22 included studies were analyzed. Placebo-adjusted ACE-I cough was 37% of 13.5% reported cases on ACE-I, while 8.5% reported cases on placebo were equivalent to 63% of cases on ACE-I, indicating potential other factors for cough than ACE-I in a substantial number of cough cases on ACE-I. Placebo-adjusted ACE-I cough had the highest rates of arterial hypertension (85%) and the lowest of heart failure (29%). Therefore, other causes of cough, particularly in heart failure, should be excluded before ACE-I withdrawal. |
DOI der Erstveröffentlichung: | 10.1002/cpt.1018 |
URL der Erstveröffentlichung: | https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.1018 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-405093 hdl:20.500.11880/36399 http://dx.doi.org/10.22028/D291-40509 |
ISSN: | 0009-9236 1532-6535 |
Datum des Eintrags: | 8-Sep-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Prof. Dr. Stefan Wagenpfeil |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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