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doi:10.22028/D291-40480
Titel: | Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma |
VerfasserIn: | Hölters, Sebastian Khalmurzaev, Oybek Pryalukhin, Alexey Loertzer, Philine Janssen, Martin Heinzelbecker, Julia Ueberdiek, Stefan Pfuhl, Thorsten Smola, Sigrun Agaimy, Abbas Geppert, Carol Loertzer, Hagen Krah, Xaver Wunderlich, Heiko Wagenpfeil, Stefan Bohle, Rainer M Stöckle, Michael Matveev, Vsevolod Hartmann, Arndt Junker, Kerstin |
Sprache: | Englisch |
Titel: | Virchows Archiv |
Bandnummer: | 475 |
Heft: | 2 |
Seiten: | 211–221 |
Verlag/Plattform: | Springer |
Erscheinungsjahr: | 2019 |
Freie Schlagwörter: | HPV Squamous penile carcinoma Prognosis |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. HPV genotyping and p16INK4a immunostaining were performed. The histological subtype and TNM were reclassified by two experienced uropathologists. Survival analyses were performed by Kaplan-Meier estimator and log-rank test. Uni- and multivariable analyses were performed by Cox proportional hazard model and Fisher's exact test for contingency analysis. HPV status was not found to be an independent prognostic factor. Histological subtypes differ in prognosis with the best outcome found in warty and the worst in basaloid carcinomas. Patients with pT1b defined by poor differentiation or lymphovascular invasion (LVI) had the shortest metastasis-free survival compared with pT1a (log-rank, p = 0.02). Lymph node metastasis and LVI were significantly associated with poor metastasis-free, cancer-specific and overall survival and could be identified as the only independent prognostic parameters. Prognostic value of TNM could not be improved using the 8th versus the 7th edition. In contrast to HPV status, histological subtypes are of prognostic value and should be an essential part of pathologic reports. The impact of the HPV status needs to be analysed in a subtype-specific manner. Parameters describing lymphatic dissemination have the highest impact on prognosis. Inclusion of tumour grade and LVI into a single T-category (pT1b) seems questionable. |
DOI der Erstveröffentlichung: | 10.1007/s00428-019-02566-0 |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00428-019-02566-0 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-404803 hdl:20.500.11880/36381 http://dx.doi.org/10.22028/D291-40480 |
ISSN: | 0945-6317 1432-2307 |
Datum des Eintrags: | 4-Sep-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle M - Prof. Dr. Stefan Wagenpfeil |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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