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Titel: Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma
VerfasserIn: Hölters, Sebastian
Khalmurzaev, Oybek
Pryalukhin, Alexey
Loertzer, Philine
Janssen, Martin
Heinzelbecker, Julia
Ueberdiek, Stefan
Pfuhl, Thorsten
Smola, Sigrun
Agaimy, Abbas
Geppert, Carol
Loertzer, Hagen
Krah, Xaver
Wunderlich, Heiko
Wagenpfeil, Stefan
Bohle, Rainer M
Stöckle, Michael
Matveev, Vsevolod
Hartmann, Arndt
Junker, Kerstin
Sprache: Englisch
Titel: Virchows Archiv
Bandnummer: 475
Heft: 2
Seiten: 211–221
Verlag/Plattform: Springer
Erscheinungsjahr: 2019
Freie Schlagwörter: HPV
Squamous penile carcinoma
Prognosis
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. HPV genotyping and p16INK4a immunostaining were performed. The histological subtype and TNM were reclassified by two experienced uropathologists. Survival analyses were performed by Kaplan-Meier estimator and log-rank test. Uni- and multivariable analyses were performed by Cox proportional hazard model and Fisher's exact test for contingency analysis. HPV status was not found to be an independent prognostic factor. Histological subtypes differ in prognosis with the best outcome found in warty and the worst in basaloid carcinomas. Patients with pT1b defined by poor differentiation or lymphovascular invasion (LVI) had the shortest metastasis-free survival compared with pT1a (log-rank, p = 0.02). Lymph node metastasis and LVI were significantly associated with poor metastasis-free, cancer-specific and overall survival and could be identified as the only independent prognostic parameters. Prognostic value of TNM could not be improved using the 8th versus the 7th edition. In contrast to HPV status, histological subtypes are of prognostic value and should be an essential part of pathologic reports. The impact of the HPV status needs to be analysed in a subtype-specific manner. Parameters describing lymphatic dissemination have the highest impact on prognosis. Inclusion of tumour grade and LVI into a single T-category (pT1b) seems questionable.
DOI der Erstveröffentlichung: 10.1007/s00428-019-02566-0
URL der Erstveröffentlichung: https://link.springer.com/article/10.1007/s00428-019-02566-0
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-404803
hdl:20.500.11880/36381
http://dx.doi.org/10.22028/D291-40480
ISSN: 0945-6317
1432-2307
Datum des Eintrags: 4-Sep-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
M - Prof. Dr. Stefan Wagenpfeil
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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