Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-40410
Titel: Activation of the Acute-Phase Response in Hemophilia
VerfasserIn: Knowles, Lynn M.
Wolter, Carolin
Menger, Michael D.
Laschke, Matthias W.
Beyer, Lars
Grün, Ulrich
Eichler, Hermann
Pilch, Jan
Sprache: Englisch
Titel: Thrombosis and Haemostasis
Bandnummer: 123
Heft: 9
Seiten: 867-879
Verlag/Plattform: Thieme
Erscheinungsjahr: 2023
Freie Schlagwörter: hemophilia
interleukin-6
bleeding
wound healing
inflammation
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: To identify recurrent inflammation in hemophilia, we assessed the acute-phase response in the blood of patients with hemophilia A and B. Compared to age- and weight-matched controls, blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and LPS-binding protein (LBP) were significantly elevated in the entire cohort of hemophilia patients but exhibited a particularly pronounced increase in obese hemophilia patients with a body mass index (BMI) 30. Subgroup analysis of the remaining nonobese hemophilia patients (BMI: 18–29.9) revealed a significant spike of IL-6, CRP, and LBP in connection with a de-novo increase of soluble IL-6 receptor α (sIL6Rα) in patients with bleeding events within the last month. Hemophilia patients who did not experience recent bleeding had IL-6, CRP, and sIL-6Rα blood levels similar to healthy controls. We did not find increased IL-6 or acute-phase reactants in hemophilia patients with arthropathy or infectious disease. The role of IL-6 as a marker of bleeding in hemophilia was confirmed in hemophilia patients with acute bleeding events as well as in transgenic hemophilia mice after needle puncture of the knee, which exhibited an extensive hematoma and a 150-fold increase of IL-6 blood levels within 7 days of the injury compared to needle-punctured control mice. Notably, IL-6 blood levels shrunk to a fourfold elevation in hemophilia mice over controls after 28 days, when the hematoma was replaced by arthrofibrosis. These findings indicate that acute-phase reactants in combination with sIL-6Rα could be sensitive biomarkers for the detection of acute and recent bleeding events in hemophilia.
DOI der Erstveröffentlichung: 10.1055/a-2071-0477
URL der Erstveröffentlichung: http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2071-0477
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-404107
hdl:20.500.11880/36325
http://dx.doi.org/10.22028/D291-40410
ISSN: 2567-689X
0340-6245
Datum des Eintrags: 30-Aug-2023
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://www.thieme-connect.de/media/10.1055-s-00035024/202309/supmat/10-1055-a-2071-0477-s22090414.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
M - Orthopädie
Professur: M - Prof. Dr. Hermann Eichler
M - Prof. Dr. Michael D. Menger
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
a-2071-0477.pdf4,73 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons