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doi:10.22028/D291-40410
Titel: | Activation of the Acute-Phase Response in Hemophilia |
VerfasserIn: | Knowles, Lynn M. Wolter, Carolin Menger, Michael D. Laschke, Matthias W. Beyer, Lars Grün, Ulrich Eichler, Hermann Pilch, Jan |
Sprache: | Englisch |
Titel: | Thrombosis and Haemostasis |
Bandnummer: | 123 |
Heft: | 9 |
Seiten: | 867-879 |
Verlag/Plattform: | Thieme |
Erscheinungsjahr: | 2023 |
Freie Schlagwörter: | hemophilia interleukin-6 bleeding wound healing inflammation |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | To identify recurrent inflammation in hemophilia, we assessed the acute-phase response in the blood of patients with hemophilia A and B. Compared to age- and weight-matched controls, blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and LPS-binding protein (LBP) were significantly elevated in the entire cohort of hemophilia patients but exhibited a particularly pronounced increase in obese hemophilia patients with a body mass index (BMI) 30. Subgroup analysis of the remaining nonobese hemophilia patients (BMI: 18–29.9) revealed a significant spike of IL-6, CRP, and LBP in connection with a de-novo increase of soluble IL-6 receptor α (sIL6Rα) in patients with bleeding events within the last month. Hemophilia patients who did not experience recent bleeding had IL-6, CRP, and sIL-6Rα blood levels similar to healthy controls. We did not find increased IL-6 or acute-phase reactants in hemophilia patients with arthropathy or infectious disease. The role of IL-6 as a marker of bleeding in hemophilia was confirmed in hemophilia patients with acute bleeding events as well as in transgenic hemophilia mice after needle puncture of the knee, which exhibited an extensive hematoma and a 150-fold increase of IL-6 blood levels within 7 days of the injury compared to needle-punctured control mice. Notably, IL-6 blood levels shrunk to a fourfold elevation in hemophilia mice over controls after 28 days, when the hematoma was replaced by arthrofibrosis. These findings indicate that acute-phase reactants in combination with sIL-6Rα could be sensitive biomarkers for the detection of acute and recent bleeding events in hemophilia. |
DOI der Erstveröffentlichung: | 10.1055/a-2071-0477 |
URL der Erstveröffentlichung: | http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2071-0477 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-404107 hdl:20.500.11880/36325 http://dx.doi.org/10.22028/D291-40410 |
ISSN: | 2567-689X 0340-6245 |
Datum des Eintrags: | 30-Aug-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Material |
In Beziehung stehendes Objekt: | https://www.thieme-connect.de/media/10.1055-s-00035024/202309/supmat/10-1055-a-2071-0477-s22090414.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie M - Orthopädie |
Professur: | M - Prof. Dr. Hermann Eichler M - Prof. Dr. Michael D. Menger M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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a-2071-0477.pdf | 4,73 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons