Please use this identifier to cite or link to this item: doi:10.22028/D291-40214
Title: Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood
Author(s): Bous, Michelle
Schmitt, Charline
Hans, Muriel Charlotte
Weber, Regine
Nourkami-Tutdibi, Nasenien
Tenbruck, Sebastian
Haj Hamoud, Bashar
Wagenpfeil, Gudrun
Kaiser, Elisabeth
Solomayer, Erich-Franz
Zemlin, Michael
Goedicke-Fritz, Sybelle
Language: English
Title: International Journal of Molecular Sciences
Volume: 24
Issue: 14
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: B cells
T cells
B1 cells
white blood cells
cord blood
sex differences
gender medicine
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Cord blood represents a link between intrauterine and early extrauterine development. Cord blood cells map an important time frame in human immune imprinting processes. It is unknown whether the sex of the newborn affects the lymphocyte subpopulations in the cord blood. Nine B and twenty-one T cell subpopulations were characterized using flow cytometry in human cord blood from sixteen male and twenty-one female newborns, respectively. Except for transitional B cells and naïve B cells, frequencies of B cell counts across all subsets was higher in the cord blood of male newborns than in female newborns. The frequency of naïve thymus-negative Th cells was significantly higher in male cord blood, whereas the remaining T cell subpopulations showed a higher count in the cord blood of female newborns. Our study is the first revealing sex differences in the B and T cell subpopulations of human cord blood. These results indicate that sex might have a higher impact for the developing immune system, urging the need to expand research in this area.
DOI of the first publication: 10.3390/ijms241411511
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-402143
ISSN: 1422-0067
Date of registration: 27-Jul-2023
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Pädiatrie
Professorship: M - Prof. Dr. E.-F. Solomayer
M - Prof. Dr. Stefan Wagenpfeil
M - Prof. Dr. Michael Zemlin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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