Please use this identifier to cite or link to this item: doi:10.22028/D291-40210
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Title: Efficacy of Antihypertensive Drugs of Different Classes After Renal Denervation in Spontaneously Hypertensive Rats
Author(s): Hohl, Mathias
Lauder, Lucas
Sevimli, Özlem
Tokcan, Mert
Wagmann, Lea
Götzinger, Felix
Schneider, Clara
Hübner, Ulrich
Lehnert, Ulrike
Meyer, Markus R.
Böhm, Michael
Mahfoud, Felix
Language: English
Title: Hypertension
Volume: 80
Issue: 6
Pages: e90-e100
Publisher/Platform: American Heart Association
Year of Publication: 2023
Free key words: antihypertensive therapy
blood pressure reduction
renal denervation
renin-angiotensin-aldosterone system
spontaneously hypertensive rats
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background:Renal denervation (RDN) lowers blood pressure (BP) in patients with uncontrolled hypertension. Limited data exist on the effectiveness of different antihypertensive medications following RDN on BP and maladaptive cardiac phenotypes. Methods:Eighty-nine male spontaneously hypertensive rats with continuous BP recording underwent RDN or sham operation. Ten days postsurgery, spontaneously hypertensive rats were randomized to receive no antihypertensive medication, amlodipine, olmesartan, hydrochlorothiazide, bisoprolol, doxazosin, or moxonidine for 28 days. Cardiac remodeling was determined histologically, and activation of the renin-angiotensin-aldosterone system was explored. Results:Before initiation of antihypertensive drugs, RDN reduced mean arterial pressure (−12.6 mm Hg [95% CI, −14.4 to −10.8]; P<0.001). At study end, mean arterial pressure was lower in RDN compared with sham operation in drug-naïve controls (P=0.006), olmesartan (P=0.002), amlodipine (P=0.0004), hydrochlorothiazide (P=0.006), doxazosin (P=0.001), and bisoprolol (P=0.039) but not in animals receiving moxonidine (P=0.122). Compared with pooled BP change of all other drug classes, mean arterial pressure change was largest for olmesartan (−15.9 mm Hg [95% CI, −18.6 to −13.2]; P<0.001) and amlodipine (−12.0 mm Hg [95% CI, −14.7 to −9.3]; P<0.001). In drug-naïve controls, RDN reduced plasma renin activity (−5.6%¸ P=0.03) and aldosterone concentration (−53.0%; P=0.005). In the presence of antihypertensive medication, plasma renin activity and aldosterone remained unchanged after RDN. Cardiac remodeling was not affected by RDN alone. In animals receiving olmesartan after RDN, cardiac perivascular fibrosis was attenuated. Amlodipine and bisoprolol following RDN reduced cardiomyocyte diameter. Conclusions:Following RDN, treatment with amlodipine and olmesartan resulted in the largest BP reduction. Antihypertensive medications mediated heterogeneous effects on renin-angiotensin-aldosterone system activity and cardiac remodeling.
DOI of the first publication: 10.1161/HYPERTENSIONAHA.122.20756
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-402103
ISSN: 1524-4563
Date of registration: 26-Jul-2023
Description of the related object: Supplemental Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Experimentelle und Klinische Pharmakologie und Toxikologie
M - Innere Medizin
Professorship: M - Prof. Dr. Michael Böhm
M - Prof. Dr. Markus Meyer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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