Please use this identifier to cite or link to this item: doi:10.22028/D291-40182
Title: Oligodendrocyte precursor cells: the multitaskers in the brain
Author(s): Fang, Li-Pao
Bai, Xianshu
Language: English
Title: Pflügers Archiv : European Journal of Physiology
Publisher/Platform: Springer Nature
Year of Publication: 2023
Free key words: Oligodendrocyte precursor cells
Neural circuits
Neuron-OPC interaction
Bloodbrain barrier
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: In the central nervous system, oligodendrocyte precursor cells (OPCs) are recognized as the progenitors responsible for the generation of oligodendrocytes, which play a critical role in myelination. Extensive research has shed light on the mechanisms underlying OPC proliferation and diferentiation into mature myelin-forming oligodendrocytes. However, recent advances in the feld have revealed that OPCs have multiple functions beyond their role as progenitors, exerting control over neural circuits and brain function through distinct pathways. This review aims to provide a comprehensive understanding of OPCs by frst introducing their well-established features. Subsequently, we delve into the emerging roles of OPCs in modulating brain function in both healthy and diseased states. Unraveling the cellular and molecular mechanisms by which OPCs infuence brain function holds great promise for identifying novel therapeutic targets for central nervous system diseases.
DOI of the first publication: 10.1007/s00424-023-02837-5
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-401820
ISSN: 1432-2013
Date of registration: 24-Jul-2023
Faculty: M - Medizinische Fakultät
Department: M - Physiologie
Professorship: M - Prof. Dr. Frank Kirchhoff
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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