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Titel: Bedside Measurement of Volatile Organic Compounds in the Atmosphere of Neonatal Incubators Using Ion Mobility Spectrometry
VerfasserIn: Steinbach, Julia
Goedicke-Fritz, Sybelle
Tutdibi, Erol
Stutz, Regine
Kaiser, Elisabeth
Meyer, Sascha
Baumbach, Jörg Ingo
Zemlin, Michael
Sprache: Englisch
Titel: Frontiers in Pediatrics
Bandnummer: 7
Verlag/Plattform: Frontiers
Erscheinungsjahr: 2019
Freie Schlagwörter: ion mobility spectrometry
neonatal incubator
preterm infant
volatile organic compound
breath analysis
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Early and non-invasive diagnosis of common diseases is of great importance in the care of preterm infants. We hypothesized that volatile organic compounds (VOC) can be successfully measured in the neonatal incubator atmosphere. Methods: This is a feasibility study to investigate whether the discrimination of occupied and unoccupied neonatal incubators is possible by bedside measurement of volatile organic compounds (VOCs) on the neonatal intensive care unit. VOC profiles were measured in the incubator air using ion mobility spectrometry coupled to multi-capillary columns (BreathDiscovery B&S Analytik GmbH, Dortmund, Germany). Results: Seventeen incubators occupied by preterm infants (50 measurements) and nine unoccupied neonatal incubators were sampled, using 37 room air measurements as controls. Three VOC signals that allow the discrimination between occupied and unoccupied incubators were identified. The best discrimination was reached by peak P20 exhibiting a sensitivity, specificity, positive predictive value and negative predictive value of 94.0, 88.9, 97.3, and 72.3%, respectively. Use of a decision tree improved these values to 100.0, 88.9, 98.0, and 100.0%, respectively. Discussion: A bedside method that allows the characterization of VOC profiles in the neonatal incubator atmosphere using ion mobility spectrometry was established. Occupied and unoccupied incubators could be discriminated by characterizing VOC profiles. This technique has the potential to yield results within minutes. Thus, future studies are recommended to test the hypothesis that VOCs within neonatal incubators are useful biomarkers for non-invasive diagnostics in preterm neonates.
DOI der Erstveröffentlichung: 10.3389/fped.2019.00248
URL der Erstveröffentlichung: https://www.frontiersin.org/articles/10.3389/fped.2019.00248
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-401693
hdl:20.500.11880/36143
http://dx.doi.org/10.22028/D291-40169
ISSN: 2296-2360
Datum des Eintrags: 21-Jul-2023
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://ndownloader.figstatic.com/files/15517109
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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