Please use this identifier to cite or link to this item: doi:10.22028/D291-39939
Title: Radiation-Induced Brain Injury : Age Dependency of Neurocognitive Dysfunction Following Radiotherapy
Author(s): Rübe, Claudia E.
Raid, Silvia
Palm, Jan
Rübe, Christian
Language: English
Title: Cancers
Volume: 15
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: ionizing radiation
radiation-induced brain injury
neurocognitive dysfunction
age dependency
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Cranial radiotherapy is a known risk factor for neurocognitive impairment in cancer survivors. Although radiation-induced cognitive dysfunction is observed in patients of all ages, children seem to be more vulnerable than adults to suffering age-related deficits in neurocognitive skills. So far, the underlying mechanisms by which IR negatively influences brain functions as well as the reasons for the profound age dependency are still insufficiently known. We performed a comprehensive Pubmed-based literature search to identify original research articles that reported on age dependency of neurocognitive dysfunction following cranial IR exposure. Numerous clinical trials in childhood cancer survivors indicate that the severity of radiation-induced cognitive dysfunction is clearly dependent on age at IR exposure. These clinical findings were related to the current state of experimental research providing important insights into the age dependency of radiationinduced brain injury and the development of neurocognitive impairment. Research in pre-clinical rodent models demonstrates age-dependent effects of IR exposure on hippocampal neurogenesis, radiation-induced neurovascular damage and neuroinflammation.
DOI of the first publication: 10.3390/cancers15112999
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-399394
ISSN: 2072-6694
Date of registration: 12-Jun-2023
Faculty: M - Medizinische Fakultät
Department: M - Radiologie
Professorship: M - Prof. Dr. Christian Rübe
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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