Please use this identifier to cite or link to this item:Volltext verfügbar? / Dokumentlieferung
|Title:||FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease|
|Author(s):||Sellier, Alexander B.|
Emrich, Insa E.
Zawada, Adam M.
Heine, Gunnar H.
|Title:||American Journal of Nephrology|
|Year of Publication:||2021|
|Free key words:||Cardiovascular disease|
Chronic kidney disease
|DDC notations:||610 Medicine and health|
|Publikation type:||Journal Article|
|Abstract:||Introduction: High plasma fibroblast growth factor 23 (FGF-23) predicts cardiovascular events in chronic kidney disease (CKD) patients. Experimental evidence suggests FGF receptor 4 (FGFR4) activation by FGF-23, and deficiency of the soluble form of its co-receptor Klotho promotes left-ventricular hypertrophy (LVH). To evaluate the clinical relevance of these findings, a Mendelian randomization study analyzed the association of genetic variants of FGFR4 and Klotho with echocardiographic parameters and cardiac events in CKD patients. Methods: The prospective Cardiovascular and Renal Outcome in CKD 2–4 Patients–The Fourth Homburg Evaluation study recruited CKD G2–G4 patients, of whom 519 consented to SNP genotyping (FGFR4: rs351855; Klotho: rs9536314). Echocardiographic examinations at baseline and 5 years later assessed prevalence of LVH by measurement of left-ventricular mass index (LVMI). Patients were followed for 5.1 ± 2.1 years for the primary endpoints of cardiac decompensation and atherosclerotic cardiovascular disease (ASCVD). Results: Carriers of the different alleles did neither differ in baseline LVMI (rs351855: p = 0.861; rs9536314: p = 0.379) nor in LVMI changes between baseline and follow-up (rs351855: p = 0.181; rs9536314: p = 0.995). Hundred and four patients suffered cardiac decompensation, and 144 patients had ASCVD. Time to cardiac decompensation (rs351855: p = 0.316; rs9536314: p = 0.765) and ASCVD (p = 0.508 and p = 0.800, respectively) did not differ between carriers of different alleles. Discussion/Conclusion: rs351855 and rs9536314 were not associated with LVMI or cardiac events. These findings do not provide evidence for a relevant clinical role of either FGFR4 stimulation or soluble form of Klotho deficiency in LVH development.|
|DOI of the first publication:||10.1159/000519274|
|URL of the first publication:||https://doi.org/10.1159/000519274|
|Link to this record:||urn:nbn:de:bsz:291--ds-399489|
|Date of registration:||12-Jun-2023|
|Description of the related object:||Supplementary Material|
|Faculty:||M - Medizinische Fakultät|
|Department:||M - Innere Medizin|
|Professorship:||M - Prof. Dr. Michael Böhm|
M - Prof. Dr. Danilo Fliser
|Collections:||SciDok - Der Wissenschaftsserver der Universität des Saarlandes|
Files for this record:
There are no files associated with this item.
Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.