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doi:10.22028/D291-39948
Titel: | FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease |
VerfasserIn: | Sellier, Alexander B. Seiler-Mußler, Sarah Emrich, Insa E. Böhm, Michael Fliser, Danilo Zawada, Adam M. Heine, Gunnar H. |
Sprache: | Englisch |
Titel: | American Journal of Nephrology |
Bandnummer: | 52 |
Heft: | 10-11 |
Seiten: | 808-816 |
Verlag/Plattform: | Karger |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Cardiovascular disease Chronic kidney disease Heart failure Left-ventricular hypertrophy Gene polymorphism |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Introduction: High plasma fibroblast growth factor 23 (FGF-23) predicts cardiovascular events in chronic kidney disease (CKD) patients. Experimental evidence suggests FGF receptor 4 (FGFR4) activation by FGF-23, and deficiency of the soluble form of its co-receptor Klotho promotes left-ventricular hypertrophy (LVH). To evaluate the clinical relevance of these findings, a Mendelian randomization study analyzed the association of genetic variants of FGFR4 and Klotho with echocardiographic parameters and cardiac events in CKD patients. Methods: The prospective Cardiovascular and Renal Outcome in CKD 2–4 Patients–The Fourth Homburg Evaluation study recruited CKD G2–G4 patients, of whom 519 consented to SNP genotyping (FGFR4: rs351855; Klotho: rs9536314). Echocardiographic examinations at baseline and 5 years later assessed prevalence of LVH by measurement of left-ventricular mass index (LVMI). Patients were followed for 5.1 ± 2.1 years for the primary endpoints of cardiac decompensation and atherosclerotic cardiovascular disease (ASCVD). Results: Carriers of the different alleles did neither differ in baseline LVMI (rs351855: p = 0.861; rs9536314: p = 0.379) nor in LVMI changes between baseline and follow-up (rs351855: p = 0.181; rs9536314: p = 0.995). Hundred and four patients suffered cardiac decompensation, and 144 patients had ASCVD. Time to cardiac decompensation (rs351855: p = 0.316; rs9536314: p = 0.765) and ASCVD (p = 0.508 and p = 0.800, respectively) did not differ between carriers of different alleles. Discussion/Conclusion: rs351855 and rs9536314 were not associated with LVMI or cardiac events. These findings do not provide evidence for a relevant clinical role of either FGFR4 stimulation or soluble form of Klotho deficiency in LVH development. |
DOI der Erstveröffentlichung: | 10.1159/000519274 |
URL der Erstveröffentlichung: | https://doi.org/10.1159/000519274 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-399489 hdl:20.500.11880/35945 http://dx.doi.org/10.22028/D291-39948 |
ISSN: | 1421-9670 0250-8095 |
Datum des Eintrags: | 12-Jun-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Material |
In Beziehung stehendes Objekt: | https://ndownloader.figstatic.com/files/31114357 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm M - Prof. Dr. Danilo Fliser |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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