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Titel: FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease
VerfasserIn: Sellier, Alexander B.
Seiler-Mußler, Sarah
Emrich, Insa E.
Böhm, Michael
Fliser, Danilo
Zawada, Adam M.
Heine, Gunnar H.
Sprache: Englisch
Titel: American Journal of Nephrology
Bandnummer: 52
Heft: 10-11
Seiten: 808-816
Verlag/Plattform: Karger
Erscheinungsjahr: 2021
Freie Schlagwörter: Cardiovascular disease
Chronic kidney disease
Heart failure
Left-ventricular hypertrophy
Gene polymorphism
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Introduction: High plasma fibroblast growth factor 23 (FGF-23) predicts cardiovascular events in chronic kidney disease (CKD) patients. Experimental evidence suggests FGF receptor 4 (FGFR4) activation by FGF-23, and deficiency of the soluble form of its co-receptor Klotho promotes left-ventricular hypertrophy (LVH). To evaluate the clinical relevance of these findings, a Mendelian randomization study analyzed the association of genetic variants of FGFR4 and Klotho with echocardiographic parameters and cardiac events in CKD patients. Methods: The prospective Cardiovascular and Renal Outcome in CKD 2–4 Patients–The Fourth Homburg Evaluation study recruited CKD G2–G4 patients, of whom 519 consented to SNP genotyping (FGFR4: rs351855; Klotho: rs9536314). Echocardiographic examinations at baseline and 5 years later assessed prevalence of LVH by measurement of left-ventricular mass index (LVMI). Patients were followed for 5.1 ± 2.1 years for the primary endpoints of cardiac decompensation and atherosclerotic cardiovascular disease (ASCVD). Results: Carriers of the different alleles did neither differ in baseline LVMI (rs351855: p = 0.861; rs9536314: p = 0.379) nor in LVMI changes between baseline and follow-up (rs351855: p = 0.181; rs9536314: p = 0.995). Hundred and four patients suffered cardiac decompensation, and 144 patients had ASCVD. Time to cardiac decompensation (rs351855: p = 0.316; rs9536314: p = 0.765) and ASCVD (p = 0.508 and p = 0.800, respectively) did not differ between carriers of different alleles. Discussion/Conclusion: rs351855 and rs9536314 were not associated with LVMI or cardiac events. These findings do not provide evidence for a relevant clinical role of either FGFR4 stimulation or soluble form of Klotho deficiency in LVH development.
DOI der Erstveröffentlichung: 10.1159/000519274
URL der Erstveröffentlichung: https://doi.org/10.1159/000519274
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-399489
hdl:20.500.11880/35945
http://dx.doi.org/10.22028/D291-39948
ISSN: 1421-9670
0250-8095
Datum des Eintrags: 12-Jun-2023
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://ndownloader.figstatic.com/files/31114357
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Michael Böhm
M - Prof. Dr. Danilo Fliser
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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