Please use this identifier to cite or link to this item: doi:10.22028/D291-39822
Title: GreenMedChem : the challenge in the next decade toward eco-friendly compounds and processes in drug design
Author(s): Castiello, Carola
Junghanns, Pierre
Mergel, Annika
Jacob, Claus
Ducho, Christian
Valente, Sergio
Rotili, Dante
Fioravanti, Rossella
Zwergel, Clemens
Mai, Antonello
Language: English
Title: Green Chemistry
Volume: 25
Issue: 6
Pages: 2109-2169
Publisher/Platform: Royal Society of Chemistry
Year of Publication: 2023
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Green chemistry has become a hot topic and the focus of not only many companies but also researchers. Green chemistry strives to identify alternative and environmentally friendly reaction conditions and simultaneously aims to increase the rates and reduce the temperature of reactions. Specifically, the goal of green chemistry is to reduce the impact of chemical substances and processes on human health and the effective elimination of environmental pollution through dedicated sustainable prevention programs. Green chemistry is based on innovative scientific solutions to solve environmental problems that arise in the laboratory. In this review, we analyse in detail each of the 12 Principles of Green Chemistry developed by Paul Anastas in 1991, emphasising the aspects of medicinal chemistry carried out in research laboratories for the synthesis of active pharmaceutical ingredients (API). Here, we provide some examples of greener reactions, which can substitute the older strategies carried out by both industries and academia and offer a guide to improve the greenness of reactions. The present review highlights the methods that can be used by medicinal chemists in their daily work not only to improve the yields but also to reduce and prevent pollution, thereby protecting the environment and our health.
DOI of the first publication: 10.1039/D2GC03772F
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398225
ISSN: 1463-9270
Date of registration: 23-May-2023
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Christian Ducho
NT - Prof. Dr. Claus Jacob
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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