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doi:10.22028/D291-39807
Titel: | Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD: An observational study |
VerfasserIn: | Emrich, Insa E. Heine, Gunnar H Schulze, P Christian Rogacev, Kyrill S Fliser, Danilo Wagenpfeil, Stefan Böhm, Michael Lütjohann, Dieter Weingärtner, Oliver |
Sprache: | Englisch |
Titel: | Pharmacology Research & Perspectives |
Bandnummer: | 9 |
Heft: | 4 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | cardiovascular disease cholesterol absorption cholesterol synthesis renal impairment |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | In dialysis patients, cholesterol-lowering therapy with statins is less effective than in other high-risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption-such as campesterol-better predict atherosclerotic cardiovascular events than markers of cholesterol synthesis-such as lathosterol-in dialysis patients. To test the association between markers of cholesterol absorption such as campesterol-and markers of cholesterol synthesis-such as lathosterol-against cardiovascular events in non-dialysis CKD patients. Altogether 251 patients those not on lipid-lowering agents were followed annually for the composite endpoint atherosclerotic cardiovascular disease (ASCVD) and all-cause death. During follow-up of 5.2 ± 2.1 years, 61 participants reached the primary endpoint atherosclerotic cardiovascular disease/all-cause death [ASCVD/D], 47 participants suffered from ASCVD, and 46 participants died. In univariate Cox regression analysis, campesterol/lathosterol ratio did not significantly predict ASCVD/D (HR 0.643; 0.358-1.155; 3rd vs. 1st tertile), all-cause death (HR 1.309; 0.604-2.838; 3rd vs. 1st tertile) nor ASCVD (HR 0.589; 0.311-1.118; 3rd vs. 1st tertile). We did not observe a shift from cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD. Campesterol/lathosterol ratio did not predict future ASCVD or all-cause death in non-dialysis CKD. |
DOI der Erstveröffentlichung: | 10.1002/prp2.801 |
URL der Erstveröffentlichung: | https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.801 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-398072 hdl:20.500.11880/35860 http://dx.doi.org/10.22028/D291-39807 |
ISSN: | 2052-1707 |
Datum des Eintrags: | 22-Mai-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Innere Medizin |
Professur: | M - Prof. Dr. Stefan Wagenpfeil M - Prof. Dr. Michael Böhm |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Pharmacology Res Perspec - 2021 - Emrich - Markers of cholesterol synthesis to cholesterol absorption across the spectrum.pdf | 547,97 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons