Please use this identifier to cite or link to this item: doi:10.22028/D291-39807
Title: Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD: An observational study
Author(s): Emrich, Insa E
Heine, Gunnar H
Schulze, P Christian
Rogacev, Kyrill S
Fliser, Danilo
Wagenpfeil, Stefan
Böhm, Michael
Lütjohann, Dieter
Weingärtner, Oliver
Language: English
Title: Pharmacology research & perspectives
Volume: 9
Issue: 4
Publisher/Platform: Wiley
Year of Publication: 2021
Free key words: cardiovascular disease
cholesterol absorption
cholesterol synthesis
renal impairment
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: In dialysis patients, cholesterol-lowering therapy with statins is less effective than in other high-risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption-such as campesterol-better predict atherosclerotic cardiovascular events than markers of cholesterol synthesis-such as lathosterol-in dialysis patients. To test the association between markers of cholesterol absorption such as campesterol-and markers of cholesterol synthesis-such as lathosterol-against cardiovascular events in non-dialysis CKD patients. Altogether 251 patients those not on lipid-lowering agents were followed annually for the composite endpoint atherosclerotic cardiovascular disease (ASCVD) and all-cause death. During follow-up of 5.2 ± 2.1 years, 61 participants reached the primary endpoint atherosclerotic cardiovascular disease/all-cause death [ASCVD/D], 47 participants suffered from ASCVD, and 46 participants died. In univariate Cox regression analysis, campesterol/lathosterol ratio did not significantly predict ASCVD/D (HR 0.643; 0.358-1.155; 3rd vs. 1st tertile), all-cause death (HR 1.309; 0.604-2.838; 3rd vs. 1st tertile) nor ASCVD (HR 0.589; 0.311-1.118; 3rd vs. 1st tertile). We did not observe a shift from cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD. Campesterol/lathosterol ratio did not predict future ASCVD or all-cause death in non-dialysis CKD.
DOI of the first publication: 10.1002/prp2.801
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398072
ISSN: 2052-1707
Date of registration: 22-May-2023
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professorship: M - Prof. Dr. Stefan Wagenpfeil
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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