Please use this identifier to cite or link to this item:
doi:10.22028/D291-39804
Title: | Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues |
Author(s): | Aoki, Mari Gamayun, Igor Wyatt, Amanda Grünewald, Ramona Simon-Thomas, Martin Philipp, Stephan E Hummel, Oliver Wagenpfeil, Stefan Kattler, Kathrin Gasparoni, Gilles Walter, Jörn Qiao, Sen Grattan, David R Boehm, Ulrich |
Language: | English |
Title: | Science advances |
Volume: | 7 |
Issue: | 41 |
Publisher/Platform: | American Association for the Advancement of Science (AAAS) |
Year of Publication: | 2021 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Chemosensory cues detected in the nose need to be integrated with the hormonal status to trigger appropriate behaviors, but the neural circuits linking the olfactory and the endocrine system are insufficiently understood. Here, we characterize olfactory sensory neurons in the murine nose that respond to the pituitary hormone prolactin. Deletion of prolactin receptor in these cells results in impaired detection of social odors and blunts male preference in females. The prolactin-responsive olfactory sensory neurons exhibit a distinctive projection pattern to the brain that is similar across different individuals and express a limited subset of chemosensory receptors. Prolactin modulates the responses within these neurons to discrete chemosensory cues contained in male urine, providing a mechanism by which the hormonal status can be directly linked with distinct olfactory cues to generate appropriate behavioral responses. |
DOI of the first publication: | 10.1126/sciadv.abg4074 |
URL of the first publication: | https://www.science.org/doi/epdf/10.1126/sciadv.abg4074 |
Link to this record: | urn:nbn:de:bsz:291--ds-398041 hdl:20.500.11880/35857 http://dx.doi.org/10.22028/D291-39804 |
ISSN: | 2375-2548 |
Date of registration: | 22-May-2023 |
Faculty: | M - Medizinische Fakultät NT - Naturwissenschaftlich- Technische Fakultät |
Department: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik NT - Biowissenschaften |
Professorship: | M - Prof. Dr. Stefan Wagenpfeil NT - Prof. Dr. Jörn Walter |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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sciadv.abg4074.pdf | Artikel | 7,58 MB | Adobe PDF | View/Open |
sciadv.abg4074_sm.pdf | Supplementary Materials | 3,65 MB | Adobe PDF | View/Open |
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