Please use this identifier to cite or link to this item: doi:10.22028/D291-39804
Title: Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues
Author(s): Aoki, Mari
Gamayun, Igor
Wyatt, Amanda
Grünewald, Ramona
Simon-Thomas, Martin
Philipp, Stephan E
Hummel, Oliver
Wagenpfeil, Stefan
Kattler, Kathrin
Gasparoni, Gilles
Walter, Jörn
Qiao, Sen
Grattan, David R
Boehm, Ulrich
Language: English
Title: Science advances
Volume: 7
Issue: 41
Publisher/Platform: American Association for the Advancement of Science (AAAS)
Year of Publication: 2021
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Chemosensory cues detected in the nose need to be integrated with the hormonal status to trigger appropriate behaviors, but the neural circuits linking the olfactory and the endocrine system are insufficiently understood. Here, we characterize olfactory sensory neurons in the murine nose that respond to the pituitary hormone prolactin. Deletion of prolactin receptor in these cells results in impaired detection of social odors and blunts male preference in females. The prolactin-responsive olfactory sensory neurons exhibit a distinctive projection pattern to the brain that is similar across different individuals and express a limited subset of chemosensory receptors. Prolactin modulates the responses within these neurons to discrete chemosensory cues contained in male urine, providing a mechanism by which the hormonal status can be directly linked with distinct olfactory cues to generate appropriate behavioral responses.
DOI of the first publication: 10.1126/sciadv.abg4074
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398041
ISSN: 2375-2548
Date of registration: 22-May-2023
Description of the related object: Supplemental Material
Related object:
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
NT - Biowissenschaften
Professorship: M - Prof. Dr. Stefan Wagenpfeil
NT - Prof. Dr. Jörn Walter
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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