Please use this identifier to cite or link to this item: doi:10.22028/D291-39796
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Title: Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study
Author(s): Knodel, Sophia
Roemer, S N
Moslemani, Kayed
Wykrota, Agata
Käsmann-Kellner, Barbara
Seitz, Berthold
Wagenpfeil, Gudrun
Faßbender, Klaus
Naldi, A
Kalampokini, S
Lochner, Piergiorgio
Language: English
Title: Journal of the neurological sciences
Volume: 430
Publisher/Platform: Elsevier
Year of Publication: 2021
Free key words: Idiopathic intracranial hypertension
Pseudotumor cerebri syndrome
Transorbital sonography
Neuro ophthalmological parameters
Optic nerve sheath diameter
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: To assess the validity of neurosonological parameters (transorbital sonography (TOS)) for detection and monitoring of patients with idiopathic intracranial hypertension (IIH). Prospective, single-center, case-controlled study in 25 patients with IIH and 19 controls. Visual parameters of papilledema, visual acuity, computerized static threshold perimetry, fundus examination, and neurosonological parameters of papilledema/optic disc elevation (ODE), optic nerve sheath diameter (ONSD) and optic nerve diameter (OND) were recorded at baseline and only for patients with IIH again within 6 months. ONSD was significantly enlarged among individuals with IIH (6.2 ± 0.73 mm) compared to controls (4.99 ± 0.54 mm; p < 0.001). Bilateral ODE was found in 36/50 eyes in patients at their initial visit and in none of the controls. Re-evaluation 6 months later showed a significant reduction of ONSD (6.0 ± 0.7 mm; p = 0.024) and ODE (0.2 (0–1) mm; p ≤0.001). Best corrected visual acuity (BCVA) and square root of lost variance (sLV) remained stable. Headache intensity (Numeric rating scale, NRS) improved significantly p < 0.001. When compared to patients with first diagnosed IIH (n = 18), the subset of patients with preexisting IIH with acute relapse (n = 7) showed persistent but reduced levels of ICP increase. They also presented significant decrease of BVCA (p = 0.01) and mean defect (MD) (p = 0.012). Re-evaluation 6 months later showed significant change in ODE in both groups. Our study confirmed that TOS and ophthalmological parameters are a valuable and non-invasive method to detect and monitor elevated ICP in IIH.
DOI of the first publication: 10.1016/j.jns.2021.118069
Link to this record: urn:nbn:de:bsz:291--ds-397967
ISSN: 0022510X
Date of registration: 17-May-2023
Faculty: M - Medizinische Fakultät
Department: M - Augenheilkunde
M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Klaus Faßbender
M - Prof. Dr. Berthold Seitz
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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