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doi:10.22028/D291-39784
Titel: | Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort |
VerfasserIn: | Stokes, Caroline Sarah Weber, Daniela Wagenpfeil, Stefan Stuetz, Wolfgang Moreno-Villanueva, María Dollé, Martijn E T Jansen, Eugène Gonos, Efstathios S Bernhardt, Jürgen Grubeck-Loebenstein, Beatrix Fiegl, Simone Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Capri, Miriam Hervonen, Antti Slagboom, P Eline Breusing, Nicolle Frank, Jan Bürkle, Alexander Franceschi, Claudio Grune, Tilman |
Sprache: | Englisch |
Titel: | The British journal of nutrition |
Bandnummer: | 128 |
Heft: | 3 |
Seiten: | 433 - 443 |
Verlag/Plattform: | Cambridge University Press |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | α-tocopherol Micronutrients Plasma Retinol Vitamin D |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Self-rated health (SRH) is associated with higher risk of death. Since low plasma levels of fat-soluble vitamins are related to mortality, we aimed to assess whether plasma concentrations of vitamins A, D and E were associated with SRH in the MARK-AGE study. We included 3158 participants (52 % female) aged between 35 and 75 years. Cross-sectional data were collected via questionnaires. An enzyme immunoassay quantified 25-hydroxyvitamin D and HPLC determined α-tocopherol and retinol plasma concentrations. The median 25-hydroxyvitamin D and retinol concentrations differed significantly (P < 0·001) between SRH categories and were lower in the combined fair/poor category v. the excellent, very good and good categories (25-hydroxvitamin D: 40·8 v. 51·9, 49·3, 46·7 nmol/l, respectively; retinol: 1·67 v. 1·75, 1·74, 1·70 µmol/l, respectively). Both vitamin D and retinol status were independently associated with fair/poor SRH in multiple regression analyses: adjusted OR (95 % CI) for the vitamin D insufficiency, deficiency and severe deficiency categories were 1·33 (1·06-1·68), 1·50 (1·17-1·93) and 1·83 (1·34-2·50), respectively; P = 0·015, P = 0·001 and P < 0·001, and for the second/third/fourth retinol quartiles: 1·44 (1·18-1·75), 1·57 (1·28-1·93) and 1·49 (1·20-1·84); all P < 0·001. No significant associations were reported for α-tocopherol quartiles. Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of these modifiable nutrients on health status are warranted. |
DOI der Erstveröffentlichung: | 10.1017/S0007114521004633 |
URL der Erstveröffentlichung: | https://doi.org/10.1017/S0007114521004633 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-397840 hdl:20.500.11880/35846 http://dx.doi.org/10.22028/D291-39784 |
ISSN: | 0007-1145 1475-2662 |
Datum des Eintrags: | 16-Mai-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Prof. Dr. Stefan Wagenpfeil |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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association-between-fat-soluble-vitamins-and-self-reported-health-status-a-cross-sectional-analysis-of-the-mark-age-cohort.pdf | 612,45 kB | Adobe PDF | Öffnen/Anzeigen |
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