Please use this identifier to cite or link to this item: doi:10.22028/D291-39754
Title: Tumor Sink Effect with Prostate-Specific Membrane Antigen-Targeted Theranostics in Patients with Metastatic Castration-Resistant Prostate Cancer: Intra-Individual Evaluations
Author(s): Burgard, Caroline
Rosar, Florian
Marlowe, Robert J.
Bartholomä, Mark
Dewes, Sebastian
Schaefer-Schuler, Andrea
Linxweiler, Johannes
Khreish, Fadi
Ezziddin, Samer
Language: English
Title: Cancers
Volume: 15
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: tumor sink effect
prostate-specific membrane antigen (PSMA)
positron emission tomography/computed tomography (PET/CT)
radioligand therapy (RLT)
metastatic castration-resistant prostate cancer (mCRPC)
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: “Tumor sink effects”, decreased physiological uptake of radiopharmaceuticals due to sequestration by a tumor, may impact radioligand therapy (RLT) toxicity and dosing. We investigated these effects with prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals in the healthy organs-at-risk (the parotid glands, kidneys, liver, and spleen) of 33 patients with metastatic castration-resistant prostate cancer (mCRPC). We retrospectively performed three intra-individual comparisons. First, we correlated changes from baseline to post-RLT (after two 177-lutetium (177Lu)-PSMA-617 cycles) in total lesional PSMA (∆TLP) and organ mean standardized uptake values (∆SUVmean). Second, in 25 RLT responders, we compared the organ SUVmean post-RLT versus that at baseline. Lastly, we correlated the baseline TLP and organ SUVmean. Data were acquired via 68-gallium-PSMA-11 positron emission tomography before the first and after the second 177Lu-PSMA-617 cycle. In the parotid glands and spleen, ∆TLP and ∆SUVmean showed a significant inverse correlation (r = −0.40, p = 0.023 and r = −0.36, p = 0.042, respectively). Additionally, in those tissues, the median organ SUVmean rose significantly from baseline after the response to RLT (p ≤ 0.022), and the baseline TLP and SUVmean were significantly negatively correlated (r = −0.44, p = 0.01 and r = −0.42, p = 0.016, respectively). These observations suggest tumor sink effects with PSMA-targeted radiopharmaceuticals in the salivary glands and spleen of patients with mCRPC.
DOI of the first publication: 10.3390/cancers15092592
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-397541
ISSN: 2072-6694
Date of registration: 16-May-2023
Faculty: M - Medizinische Fakultät
Department: M - Radiologie
M - Urologie und Kinderurologie
Professorship: M - Prof. Dr. Samer Ezziddin
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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