Please use this identifier to cite or link to this item: doi:10.22028/D291-39773
Title: Liver phenotypes in PCOS : Analysis of exogenous and inherited risk factors for liver injury in two European cohorts
Author(s): Smyk, Wiktor
Papapostoli, Ifigeneia
Żorniak, Michał
Sklavounos, Panagiotis
Blukacz, Łukasz
Madej, Paweł
Koutsou, Andreani
Weber, Susanne N.
Friesenhahn-Ochs, Bettina
Cebula, Maciej
Bosowska, Joanna
Solomayer, Erich-Franz
Hartleb, Marek
Milkiewicz, Piotr
Lammert, Frank
Stokes, Caroline S.
Krawczyk, Marcin
Language: English
Title: Liver International
Volume: 43
Issue: 5
Pages: 1080-1088
Publisher/Platform: Wiley
Year of Publication: 2023
Free key words: fatty liver
polycystic ovary
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background & Aims Fatty liver disease (FLD) is common in women with polycystic ovary syndrome (PCOS). Here, we use non-invasive tests to quantify liver injury in women with PCOS and analyse whether FLD-associated genetic variants contribute to liver phenotypes in PCOS. Methods Prospectively, we recruited women with PCOS and controls at two university centres in Germany and Poland. Alcohol abuse was regarded as an exclusion criterion. Genotyping of variants associated with FLD was performed using TaqMan assays. Liver stiffness measurements (LSM), controlled attenuation parameters (CAP) and non-invasive HSI, FLI, FIB-4 scores were determined to assess hepatic steatosis and fibrosis. Results A total of 42 German (age range 18–53 years) and 143 Polish (age range 18–40 years) women with PCOS, as well as 245 German and 289 Polish controls were recruited. In contrast to Polish patients, Germans were older, presented with more severe metabolic profiles and had significantly higher LSM (median 5.9 kPa vs. 3.8 kPa). In the German cohort, carriers of the PNPLA3 p.I148M risk variant had an increased LSM (p = .01). In the Polish cohort, the minor MTARC1 allele was linked with significantly lower serum aminotransferases activities, whereas the HSD17B13 polymorphism was associated with lower concentrations of 17-OH progesterone, total testosterone, and androstenedione (all p < .05). Conclusions FLD is common in women with PCOS. Its extent is modulated by both genetic and metabolic risk factors. Genotyping of variants associated with FLD might help to stratify the risk of liver disease progression in women suffering from PCOS.
DOI of the first publication: 10.1111/liv.15527
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-397738
ISSN: 1478-3231
Date of registration: 16-May-2023
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
M - Innere Medizin
Professorship: M - Prof. Dr. Frank Lammert
M - Prof. Dr. E.-F. Solomayer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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