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Titel: Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
VerfasserIn: Trouillet, Anne-Charlotte
Keller, Matthieu
Weiss, Jan
Leinders-Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
Sprache: Englisch
Titel: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Bandnummer: 116
Heft: 11
Seiten: 5135-5143
Verlag/Plattform: National Academy of Sciences
Erscheinungsjahr: 2019
Freie Schlagwörter: olfactory
GCamp6f
V1R receptor
infant-directed aggression
territorial aggression
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male–male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male–male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infantdirected aggression and decreased activity in MeA neurons during male–infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein α-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2+ VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infantdirected aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
DOI der Erstveröffentlichung: 10.1073/pnas.1821492116
URL der Erstveröffentlichung: https://doi.org/10.1073/pnas.1821492116
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-397318
hdl:20.500.11880/35802
http://dx.doi.org/10.22028/D291-39731
ISSN: 1091-6490
0027-8424
Datum des Eintrags: 10-Mai-2023
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://www.pnas.org/doi/suppl/10.1073/pnas.1821492116/suppl_file/pnas.1821492116.sapp.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Trese Leinders-Zufall
M - Prof. Dr. Frank Zufall
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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