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Titel: The Role of the Oligodendrocyte Lineage in Acute Brain Trauma
VerfasserIn: Scheller, Anja
Bai, Xianshu
Kirchhoff, Frank
Sprache: Englisch
Titel: Neurochemical Research
Bandnummer: 42
Heft: 9
Seiten: 2479-2489
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2017
Freie Schlagwörter: Oligodendrocytes
Oligodendrocyte precursor
NG2 glia
Traumatic brain injury
Myelination
Astrocytes
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: An acute brain injury is commonly characterized by an extended cellular damage. The post-injury process of scar formation is largely determined by responses of various local glial cells and blood-derived immune cells. The role of astrocytes and microglia have been frequently reviewed in the traumatic sequelae. Here, we summarize the diverse contributions of oligodendrocytes (OLs) and their precursor cells (OPCs) in acute injuries. OLs at the lesion site are highly sensitive to a damaging insult, provoked by Ca2+ overload after hyperexcitation originating from increased levels of transmitters. At the lesion site, differentiating OPCs can replace injured oligodendrocytes to guarantee proper myelination that is instrumental for healthy brain function. In contrast to finally differentiated and non-dividing OLs, OPCs are the most proliferative cells of the brain and their proliferation rate even increases after injury. There exist even evidence that OPCs might also generate some type of astrocyte beside OLs. Thereby, OPCs can contribute to the generation and maintenance of the glial scar. In the future, detailed knowledge of the molecular cues that help to prevent injury-evoked glial cell death and that control differentiation and myelination of the oligodendroglial lineage will be pivotal in developing novel therapeutic approaches.
DOI der Erstveröffentlichung: 10.1007/s11064-017-2343-4
URL der Erstveröffentlichung: https://link.springer.com/article/10.1007/s11064-017-2343-4
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-395671
hdl:20.500.11880/35662
http://dx.doi.org/10.22028/D291-39567
ISSN: 1573-6903
0364-3190
Datum des Eintrags: 18-Apr-2023
Bezeichnung des in Beziehung stehenden Objekts: Electronic supplementary material
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1007%2Fs11064-017-2343-4/MediaObjects/11064_2017_2343_MOESM1_ESM.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Frank Kirchhoff
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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