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doi:10.22028/D291-39558
Titel: | During Development NG2 Glial Cells of the Spinal Cord are Restricted to the Oligodendrocyte Lineage, but Generate Astrocytes upon Acute Injury |
VerfasserIn: | Huang, Wenhui Bai, Xianshu Stopper, Laura Catalin, Bogdan Cartarozzi, Luciana Politti Scheller, Anja Kirchhoff, Frank |
Sprache: | Englisch |
Titel: | Neuroscience |
Bandnummer: | 385 |
Seiten: | 154-165 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2018 |
Freie Schlagwörter: | NG2 glia differentiation spinal cord oligodendrocytes astrocytes spinal cord injury |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | NG2 glia are self-renewal cells widely populating the entire central nervous system (CNS). The differentiation potential of NG2 glia in the brain has been systematically studied. However, the fate of NG2 glia in the spinal cord during development and after injury is still unclear. Here, we took advantage of faithful expression of Cre in NG2-CreERT2 knock-in mice to demonstrate that spinal NG2 glia remain committed to the oligodendrocyte (OL) lineage and generate OLs, but not astrocytes or neurons, during development. However, we found significant age- and region dependent differences in differentiation into OLs. Embryonic or neonatal NG2 glia generated more than 90% of the white matter OLs, but only 50% (embryonic) or 75% (neonatal) of gray matter OLs. Such differences disappeared after myelin completion coinciding with a decrease in the differentiation rate. While we never detected the generation of astrocytes from NG2 glia during spinal cord development, we found a small portion of NG2 glia could generate astrocytes in adult spinal cord upon acute traumatic injury. |
DOI der Erstveröffentlichung: | 10.1016/j.neuroscience.2018.06.015 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/abs/pii/S0306452218304263 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-395588 hdl:20.500.11880/35653 http://dx.doi.org/10.22028/D291-39558 |
ISSN: | 0306-4522 |
Datum des Eintrags: | 17-Apr-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Physiologie |
Professur: | M - Prof. Dr. Frank Kirchhoff |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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