Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-39558
Volltext verfügbar? / Dokumentlieferung
Titel: During Development NG2 Glial Cells of the Spinal Cord are Restricted to the Oligodendrocyte Lineage, but Generate Astrocytes upon Acute Injury
VerfasserIn: Huang, Wenhui
Bai, Xianshu
Stopper, Laura
Catalin, Bogdan
Cartarozzi, Luciana Politti
Scheller, Anja
Kirchhoff, Frank
Sprache: Englisch
Titel: Neuroscience
Bandnummer: 385
Seiten: 154-165
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2018
Freie Schlagwörter: NG2 glia
differentiation
spinal cord
oligodendrocytes
astrocytes
spinal cord injury
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: NG2 glia are self-renewal cells widely populating the entire central nervous system (CNS). The differentiation potential of NG2 glia in the brain has been systematically studied. However, the fate of NG2 glia in the spinal cord during development and after injury is still unclear. Here, we took advantage of faithful expression of Cre in NG2-CreERT2 knock-in mice to demonstrate that spinal NG2 glia remain committed to the oligodendrocyte (OL) lineage and generate OLs, but not astrocytes or neurons, during development. However, we found significant age- and region dependent differences in differentiation into OLs. Embryonic or neonatal NG2 glia generated more than 90% of the white matter OLs, but only 50% (embryonic) or 75% (neonatal) of gray matter OLs. Such differences disappeared after myelin completion coinciding with a decrease in the differentiation rate. While we never detected the generation of astrocytes from NG2 glia during spinal cord development, we found a small portion of NG2 glia could generate astrocytes in adult spinal cord upon acute traumatic injury.
DOI der Erstveröffentlichung: 10.1016/j.neuroscience.2018.06.015
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/abs/pii/S0306452218304263
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-395588
hdl:20.500.11880/35653
http://dx.doi.org/10.22028/D291-39558
ISSN: 0306-4522
Datum des Eintrags: 17-Apr-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Frank Kirchhoff
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.


Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.