Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-39556
Titel: | Microglia morphology in the physiological and diseased brain : from fixed tissue to in vivo conditions |
VerfasserIn: | Stopper, Laura Balseanu, Tudor-Adrian Catalin, Bogdan Rogoveanu, Otilia-Constantina Mogoanta, Laurentiu Scheller, Anja |
Sprache: | Englisch |
Titel: | Romanian Journal of Morphology and Embryology |
Bandnummer: | 59 |
Heft: | 1 |
Seiten: | 7-12 |
Verlag/Plattform: | University of Medicine and Pharmacy of Craiova |
Erscheinungsjahr: | 2018 |
Freie Schlagwörter: | microglia morphology dynamics |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | First mentioned almost 100 years ago, neuroresearch has linked microglia to the initiation and/or maintenance of most central nervous system pathologies. Since their discovery, we learned that the microglia immune status is often correlated directly to their morphology. However, only recently, have we realized that, in vivo microglia are extremely dynamic cells capable to respond within minutes. Therefore, the name “resting” microglia is replaced slowly with surveilling microglia. Even more recent, it has been shown that microglia change their morphology and/or immune status depending on the way the tissue is obtained, processed and imaged, making labeling microglia, based on their morphology alone, as active or surveying even more difficult. All these observations correlated with a better understanding of cellular and subcellular process that microglia undergo in pathological conditions, could have profound implications on the time window and/or targets used to ensure the best outcome, when treating brain disease. |
URL der Erstveröffentlichung: | https://rjme.ro/archive/59/1/1/ |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-395569 hdl:20.500.11880/35651 http://dx.doi.org/10.22028/D291-39556 |
ISSN: | 2066–8279 1220–0522 |
Datum des Eintrags: | 17-Apr-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Physiologie |
Professur: | M - Prof. Dr. Frank Kirchhoff |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.