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Titel: Microglia morphology in the physiological and diseased brain : from fixed tissue to in vivo conditions
VerfasserIn: Stopper, Laura
Balseanu, Tudor-Adrian
Catalin, Bogdan
Rogoveanu, Otilia-Constantina
Mogoanta, Laurentiu
Scheller, Anja
Sprache: Englisch
Titel: Romanian Journal of Morphology and Embryology
Bandnummer: 59
Heft: 1
Seiten: 7-12
Verlag/Plattform: University of Medicine and Pharmacy of Craiova
Erscheinungsjahr: 2018
Freie Schlagwörter: microglia
morphology
dynamics
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: First mentioned almost 100 years ago, neuroresearch has linked microglia to the initiation and/or maintenance of most central nervous system pathologies. Since their discovery, we learned that the microglia immune status is often correlated directly to their morphology. However, only recently, have we realized that, in vivo microglia are extremely dynamic cells capable to respond within minutes. Therefore, the name “resting” microglia is replaced slowly with surveilling microglia. Even more recent, it has been shown that microglia change their morphology and/or immune status depending on the way the tissue is obtained, processed and imaged, making labeling microglia, based on their morphology alone, as active or surveying even more difficult. All these observations correlated with a better understanding of cellular and subcellular process that microglia undergo in pathological conditions, could have profound implications on the time window and/or targets used to ensure the best outcome, when treating brain disease.
URL der Erstveröffentlichung: https://rjme.ro/archive/59/1/1/
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-395569
hdl:20.500.11880/35651
http://dx.doi.org/10.22028/D291-39556
ISSN: 2066–8279
1220–0522
Datum des Eintrags: 17-Apr-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Frank Kirchhoff
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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