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Titel: Enteric Glia: S100, GFAP, and Beyond
VerfasserIn: Grundmann, David
Loris, Eva
Maas-Omlor, Silke
Huang, Wenhui
Scheller, Anja
Kirchhoff, Frank
Schäfer, Karl-Herbert
Sprache: Englisch
Titel: Anatomical Record
Bandnummer: 302
Heft: 8
Seiten: 1333-1344
Verlag/Plattform: Wiley
Erscheinungsjahr: 2019
Freie Schlagwörter: enteric glia
GFAP
S100
PLP-1
NG2
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Since several years, the enteric nervous system (ENS) is getting more and more in the focus of gastrointestinal research. While the main interest was credited for years to the enteric neurons and their functional properties, less attention has been paid on the enteric glial cells (EGCs). Although the similarity of EGCs to central nervous system (CNS) astrocytes has been demonstrated a long time ago, EGCs were investigated in more detail only recently. Similar to the CNS, there is not “the” EGC, but also a broad range of diversity. Based on morphology and protein expression, such as glial fibrillary acidic protein (GFAP), S100, or Proteolipid-protein-1 (PLP1), several distinct glial types can be differentiated. Their heterogeneity in morphology, localization, and transcription as well as interaction with surrounding cells indicate versatile functional properties of these cells for gut function in health and disease. Although NG2 is found in a subset of CNS glial cells, it did not colocalize with the glial marker S100 or GFAP in the ENS. Instead, it in part colocalize with PDGFRα, as it does in the CNS, which do stain fibroblast-like cells in the gastrointestinal tract. Moreover, there seem to be species dependent differences. While GFAP is always found in the rodent ENS, this is completely different for the human gut. Only the compromised human ENS shows a significant amount of GFAPpositive glial cells. So, in general we can conclude that the EGC population is species specific and as complex as CNS glia. Anat Rec, 302:1333–1344, 2019. © 2019 Wiley Periodicals, Inc.
DOI der Erstveröffentlichung: 10.1002/ar.24128
URL der Erstveröffentlichung: https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.24128
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-395539
hdl:20.500.11880/35649
http://dx.doi.org/10.22028/D291-39553
ISSN: 1932-8494
1932-8486
Datum des Eintrags: 17-Apr-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Physiologie
Professur: M - Prof. Dr. Frank Kirchhoff
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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