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Titel: 'Flying high?'-Jump from a height in a 'Spice' high? : A case report on the synthetic cannabinoid 5F-MDMB-P7AICA
VerfasserIn: Walle, Nadja
Doerr, Adrian A.
Schmidt, Peter H.
Schaefer, Nadine
Sprache: Englisch
Titel: Drug Testing and Analysis
Bandnummer: 15 (2023)
Heft: 3
Seiten: 368-373
Verlag/Plattform: Wiley
Erscheinungsjahr: 2022
Freie Schlagwörter: 5F-MDMB-P7AICA
ester hydrolysis
fatal case
synthetic cannabinoid
DDC-Sachgruppe: 500 Naturwissenschaften
610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Regarding the high potency of synthetic cannabinoids (SC), many intoxications and fatal cases are reported in literature. Here, we report on a fatality with 5F-MDMBP7AICA contributing to the occurrence of death. A 31-year-old man died 10 h after he fell from the rooftop of a house. Police investigations revealed that he had consumed a ‘legal high’ herbal blend some hours earlier. An initial toxicological screening for new psychoactive substances (NPS) was negative. One year after, the analysis of confiscated drug samples revealed the SC 5F-MDMB-P7AICA being unknown at the time of the first investigations. Hence, post-mortem specimens were retrospectively analysed for 5F-MDMB-P7AICA and its dimethylbutanoic acid (DBA) metabolite. Lung, liver, kidney and bile fluid (BF) of the decedent were analysed following solidphase extraction and standard addition, heart blood (HB) and peripheral blood (PB) by fully validated liquid–liquid extraction and protein precipitation methods. Additionally, hair specimens were analysed to examine a possible chronic consumption of the SC. All specimens were analysed by liquid–chromatography tandem mass spectrometry. 5F-MDMB-P7AICA was detected in HB (0.69 ng/ml), PB (1.2 ng/ml) and hair. DBA was found in HB (46 ng/ml) and PB (5.7 ng/ml) and could additionally be identified in liver and kidney (approximately 4–5 ng/g), lung (approximately 12 ng/g) and BF (approximately 60 ng/g). Compared with the parent compound, much higher concentrations of DBA were quantified. This case shows that drugs found at the scene can provide helpful initial information for further toxicological screenings in biological samples, especially when there is evidence of NPS consumption.
DOI der Erstveröffentlichung: 10.1002/dta.3401
URL der Erstveröffentlichung: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3401
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-394714
hdl:20.500.11880/35595
http://dx.doi.org/10.22028/D291-39471
ISSN: 1942-7611
1942-7603
Datum des Eintrags: 5-Apr-2023
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://analyticalsciencejournals.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fdta.3401&file=dta3401-sup-0001-Supplementary_clean.docx
https://analyticalsciencejournals.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fdta.3401&file=dta3401-sup-0002-Supplementary_Figure_1_corr.tif
https://analyticalsciencejournals.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fdta.3401&file=dta3401-sup-0003-Supplementary_Figure_2.tif
https://analyticalsciencejournals.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fdta.3401&file=dta3401-sup-0004-Supplementary_Figure_3.tif
https://analyticalsciencejournals.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fdta.3401&file=dta3401-sup-0005-Supplementary_Figure_4.tif
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Rechtsmedizin
Professur: M - Prof. Dr. Peter Schmidt
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons