Please use this identifier to cite or link to this item: doi:10.22028/D291-39385
Title: Suppression of endothelial miR-22 mediates non-small cell lung cancer cell-induced angiogenesis
Author(s): Gu, Yuan
Pais, Gianni
Becker, Vivien
Körbel, Christina
Ampofo, Emmanuel
Ebert, Elke
Hohneck, Johannes
Ludwig, Nicole
Meese, Eckart
Bohle, Rainer M.
Zhao, Yingjun
Menger, Michael D.
Laschke, Matthias W.
Language: English
Title: Molecular Therapy : Nucleic Acids
Volume: 26
Pages: 849-864
Publisher/Platform: Elsevier
Year of Publication: 2021
Free key words: AKT
endothelial cells
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: MicroRNAs (miRNAs) expressed in endothelial cells (ECs) are powerful regulators of angiogenesis, which is essential for tumor growth and metastasis. Here, we demonstrated that miR-22 is preferentially and highly expressed in ECs, while its endothelial level is significantly downregulated in human non-small cell lung cancer (NSCLC) tissues when compared to matched nontumor lung tissues. This reduction of endothelial miR-22 is possibly induced by NSCLC cell-secreted interleukin-1b and subsequently activated transcription factor nuclear factor-kB. Endothelial miR-22 functions as a potent angiogenesis inhibitor that inhibits all of the key angiogenic activities of ECs and consequently NSCLC growth through directly targeting sirtuin 1 and fibroblast growth factor receptor 1 in ECs, leading to inactivation of AKT/mammalian target of rapamycin signaling. These findings provide insight into the molecular mechanisms of NSCLC angiogenesis and indicate that endothelial miR-22 represents a potential target for the future antiangiogenic treatment of NSCLC.
DOI of the first publication: 10.1016/j.omtn.2021.10.003
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-393851
ISSN: 2162-2531
Date of registration: 28-Mar-2023
Description of the related object: Supplemental information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
M - Humangenetik
M - Pathologie
Professorship: M - Prof. Dr. Rainer M. Bohle
M - Prof. Dr. Eckhart Meese
M - Prof. Dr. Michael D. Menger
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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