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Titel: Lighting the Path : Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo
VerfasserIn: Pearson, Samuel
Feng, Jun
del Campo, Aránzazu
Sprache: Englisch
Titel: Advanced Functional Materials
Bandnummer: 31
Heft: 50
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: biomaterials
photoactivation
photoresponsive
upconversion nanoparticles
waveguides
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Photoresponsive biomaterials are experiencing a transition from in vitro models to in vivo demonstrations that point toward clinical translation. Dynamic hydrogels for cell encapsulation, light-responsive carriers for controlled drug delivery, and nanomaterials containing photosensitizers for photodynamic therapy are relevant examples. Nonetheless, the step to the clinic largely depends on their combination with technologies to bring light into the body. This review highlights the challenge of photoactivation in vivo, and presents strategies for light management that can be adopted for this purpose. The authors’ focus is on technologies that are materials-driven, particularly upconversion nanoparticles that assist in “direct path” light delivery through tissue, and optical waveguides that “clear the path” between external light source and in vivo target. The authors’ intention is to assist the photoresponsive biomaterials community transition toward medical technologies by presenting light delivery concepts that can be integrated with the photoresponsive targets. The authors also aim to stimulate further innovation in materials-based light delivery platforms by highlighting needs and opportunities for in vivo photoactivation of biomaterials.
DOI der Erstveröffentlichung: 10.1002/adfm.202105989
URL der Erstveröffentlichung: https://doi.org/10.1002/adfm.202105989
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-393566
hdl:20.500.11880/35485
http://dx.doi.org/10.22028/D291-39356
ISSN: 1616-301X
1616-3028
Datum des Eintrags: 22-Mär-2023
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Chemie
Professur: NT - Prof. Dr. Aránzazu del Campo
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons