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Titel: Antimicrobial Use in Pediatric Oncology and Hematology: Protocol for a Multicenter Point-Prevalence Study With Qualitative Expert Panel Assessment
VerfasserIn: Papan, Cihan
Reifenrath, Katharina
Last, Katharina
Attarbaschi, Andishe
Graf, Norbert
Groll, Andreas H.
Huebner, Johannes
Laws, Hans-Jürgen
Lehrnbecher, Thomas
Liese, Johannes
Martin, Luise
Tenenbaum, Tobias
Weichert, Stefan
Vieth, Simon
von Both, Ulrich
Hufnagel, Markus
Simon, Arne
Sprache: Englisch
Titel: JMIR Research Protocols
Bandnummer: 11
Heft: 6
Verlag/Plattform: JMIR Publications
Erscheinungsjahr: 2022
Freie Schlagwörter: point-prevalence study
antimicrobial stewardship
pediatric oncology
pediatric hematology
expert panel
antimicrobial resistance
oncology
cancer
pediatrics
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: Because infections are a major driver of morbidity and mortality in children with hematologic or oncologic diseases, antimicrobials are frequently prescribed in pediatric oncology practice. However, excess or inappropriate use of antimicrobials is directly linked to the emergence of antimicrobial resistance. Although point-prevalence studies have examined the extent of antimicrobial use, a comprehensive qualitative evaluation of individual antimicrobial prescriptions remains lacking. Objective: The aim of this study is to identify appropriate versus inappropriate antimicrobial use among pediatric cancer patients in a point-prevalence study, followed by an expert panel adjudication process and a subsequent report of these findings to participating centers. This study also aims to improve the quality of patient care by informing centers about discrepancies between internal standards of care and national guidelines. Methods: Our point-prevalence study is performed at pediatric cancer centers in Germany and Austria. All patients under 18 years old who are hospitalized at the time of the study are included. As a supplement to the point-prevalence study, an expert panel is qualitatively assessing each of the antimicrobial prescriptions at the participating centers to review local guidelines and compare them with national guidelines. Results: As of December 2021, the point-prevalence survey has been conducted at 30 sites and expert panel adjudication for qualitative assessment of each antimicrobial use is ongoing. Results of the study are expected in 2022. Conclusions: This is the first point-prevalence study conducted among pediatric cancer centers with an integrated, multistep, qualitative approach that assesses each antimicrobial prescription. The results of this study will inform possible interventions for internal guidelines and antimicrobial stewardship programs implemented at pediatric cancer centers. In addition, local guidelines will be compared with national guidelines. Furthermore, this study will contribute to the overall integration of antimicrobial stewardship principles and initiatives in pediatric oncology and hematology, thereby improving safety and quality of care for children and adolescents with cancer and blood disorders.
DOI der Erstveröffentlichung: 10.2196/35774
URL der Erstveröffentlichung: https://www.researchprotocols.org/2022/6/e35774
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-392688
hdl:20.500.11880/35395
http://dx.doi.org/10.22028/D291-39268
ISSN: 1929-0748
Datum des Eintrags: 10-Mär-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
M - Pädiatrie
Professur: M - Prof. Dr. Sören Becker
M - Prof. Dr. Norbert Graf
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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