Please use this identifier to cite or link to this item: doi:10.22028/D291-38925
Title: Augmented interaction of multivalent arginine coated gold nanoclusters with lipid membranes and cells
Author(s): Porret, Estelle
Fleury, Jean-Baptiste
Sancey, Lucie
Pezet, Mylène
Coll, Jean-Luc
Le Guével, Xavier
Language: English
Title: RSC Advances
Volume: 10
Issue: 11
Pages: 6436-6443
Publisher/Platform: Royal Society of Chemistry
Year of Publication: 2020
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: A library of ultra-small red photoluminescent gold nanoclusters (Au NCs) were synthesized with an increasing amount of positive charges provided by the addition of mono-, di- or trivalent-glutathione modified arginine peptides. We then studied how the arginine content impacted on the interaction of Au NCs with negatively charged artificial lipid bilayers and cell membranes. Results indicated that increasing the arginine content enhanced Au NCs' adsorption on lipid bilayers and on cell membranes followed by an increased cellular uptake in melanoma cells (COLO 829). Surprisingly, the presence of up to 40% serum for highly positively charged Au NCs did not hinder their interaction with lipid bilayers that contain glycolipids, suggesting a reduced opsonization of these Au NCs. In addition, these Au NCs are usually not toxic, except those with the highest arginine contents. Thus, controlled grafting of arginine peptides onto Au NCs is an elegant strategy to improve their binding and internalization by tumor cells while still keeping their anti-fouling properties.
DOI of the first publication: 10.1039/C9RA10047D
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-389250
ISSN: 2046-2069
Date of registration: 6-Feb-2023
Description of the related object: Electronic supplementary information
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Ralf Seemann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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