Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-38887
Titel: Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source : A prospective, multicentre cohort study
VerfasserIn: Papan, Cihan
Argentiero, Alberto
Adams, Ortwin
Porwoll, Marian
Hakim, Ummaya
Farinelli, Edoardo
Testa, Ilaria
Pasticci, Maria B.
Mezzetti, Daniele
Perruccio, Katia
Simon, Arne
Liese, Johannes G.
Knuf, Markus
Stein, Michal
Yacobov, Renata
Bamberger, Ellen
Schneider, Sven
Esposito, Susanna
Tenenbaum, Tobias
Sprache: Englisch
Titel: Journal of Medical Virology
Bandnummer: 95 (2023)
Heft: 1
Verlag/Plattform: Wiley
Erscheinungsjahr: 2022
Freie Schlagwörter: adenovirus
biomarkers
CRP
host response
host‐protein signature
influenza
IP‐10
rhinovirus
RSV
severity
TRAIL
viral load
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background To investigate the association of viral load (VL) with (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10, C-reactive protein, and a combinatorial score (BV score), and (ii) clinical severity. Study Design In this prospective, multicentre cohort substudy, children with respiratory tract infection or fever without source were enrolled. VL for influenza virus, rhinovirus, respiratory syncytial virus, and adenovirus was measured from nasopharyngeal swabs. The reference standard diagnosis was established based on expert panel adjudication. Results Of 1140 recruited patients, 333 had a virus monodetection. VL for the aggregated data set correlated with TRAIL and IP-10 levels, with the length of oxygen therapy, and inversely with the BV score. At a single viral level, only the influenza VL yielded a correlation with TRAIL, IP-10 levels, and the BV score. Children with a viral reference standard diagnosis had significantly higher VL than those with bacterial infection (p = 0.0005). Low TRAIL (incidence rate ratio [IRR] 0.6, 95% confidence interval [CI] 0.39–0.91) and young age (IRR 0.62, 95% CI 0.49–0.79) were associated with a longer hospital stay, while young age (IRR 0.33, 95% CI 0.18–0.61), low TRAIL (IRR 0.25, 95% CI 0.08–0.76), and high VL (IRR 1.16, 95% CI 1.00–1.33) were predictive of longer oxygen therapy. Conclusion These findings indicate that VL correlates with biomarkers and may serve as a complementary tool pertaining to disease severity.
DOI der Erstveröffentlichung: 10.1002/jmv.28113
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28113
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-388870
hdl:20.500.11880/35085
http://dx.doi.org/10.22028/D291-38887
ISSN: 1096-9071
0146-6615
Datum des Eintrags: 2-Feb-2023
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjmv.28113&file=jmv28113-sup-0001-Papan_viral_load_Supplement_REVISED_210622.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
M - Pädiatrie
Professur: M - Prof. Dr. Sören Becker
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons