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doi:10.22028/D291-38887
Titel: | Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source : A prospective, multicentre cohort study |
VerfasserIn: | Papan, Cihan Argentiero, Alberto Adams, Ortwin Porwoll, Marian Hakim, Ummaya Farinelli, Edoardo Testa, Ilaria Pasticci, Maria B. Mezzetti, Daniele Perruccio, Katia Simon, Arne Liese, Johannes G. Knuf, Markus Stein, Michal Yacobov, Renata Bamberger, Ellen Schneider, Sven Esposito, Susanna Tenenbaum, Tobias |
Sprache: | Englisch |
Titel: | Journal of Medical Virology |
Bandnummer: | 95 (2023) |
Heft: | 1 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | adenovirus biomarkers CRP host response host‐protein signature influenza IP‐10 rhinovirus RSV severity TRAIL viral load |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background To investigate the association of viral load (VL) with (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10, C-reactive protein, and a combinatorial score (BV score), and (ii) clinical severity. Study Design In this prospective, multicentre cohort substudy, children with respiratory tract infection or fever without source were enrolled. VL for influenza virus, rhinovirus, respiratory syncytial virus, and adenovirus was measured from nasopharyngeal swabs. The reference standard diagnosis was established based on expert panel adjudication. Results Of 1140 recruited patients, 333 had a virus monodetection. VL for the aggregated data set correlated with TRAIL and IP-10 levels, with the length of oxygen therapy, and inversely with the BV score. At a single viral level, only the influenza VL yielded a correlation with TRAIL, IP-10 levels, and the BV score. Children with a viral reference standard diagnosis had significantly higher VL than those with bacterial infection (p = 0.0005). Low TRAIL (incidence rate ratio [IRR] 0.6, 95% confidence interval [CI] 0.39–0.91) and young age (IRR 0.62, 95% CI 0.49–0.79) were associated with a longer hospital stay, while young age (IRR 0.33, 95% CI 0.18–0.61), low TRAIL (IRR 0.25, 95% CI 0.08–0.76), and high VL (IRR 1.16, 95% CI 1.00–1.33) were predictive of longer oxygen therapy. Conclusion These findings indicate that VL correlates with biomarkers and may serve as a complementary tool pertaining to disease severity. |
DOI der Erstveröffentlichung: | 10.1002/jmv.28113 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28113 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-388870 hdl:20.500.11880/35085 http://dx.doi.org/10.22028/D291-38887 |
ISSN: | 1096-9071 0146-6615 |
Datum des Eintrags: | 2-Feb-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjmv.28113&file=jmv28113-sup-0001-Papan_viral_load_Supplement_REVISED_210622.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Infektionsmedizin M - Pädiatrie |
Professur: | M - Prof. Dr. Sören Becker M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Journal of Medical Virology - 2022 - Papan - Association of viral load with TRAIL IP‐10 CRP biomarker signature and.pdf | 2,03 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons