Please use this identifier to cite or link to this item: doi:10.22028/D291-38794
Title: Synapse Dysfunctions in Multiple Sclerosis
Author(s): Schwarz, Karin
Schmitz, Frank
Language: English
Title: International Journal of Molecular Sciences
Volume: 24
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: multiple sclerosis
ionotropic glutamate receptors
glutamate excitotoxicity
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide. In MS, cells of an auto-reactive immune system invade the brain and cause neuroinflammation. Neuroinflammation triggers a complex, multi-faceted harmful process not only in the white matter but also in the grey matter of the brain. In the grey matter, neuroinflammation causes synapse dysfunctions. Synapse dysfunctions in MS occur early and independent from white matter demyelination and are likely correlates of cognitive and mental symptoms in MS. Disturbed synapse/glia interactions and elevated neuroinflammatory signals play a central role. Glutamatergic excitotoxic synapse damage emerges as a major mechanism. We review synapse/glia communication under normal conditions and summarize how this communication becomes malfunctional during neuroinflammation in MS. We discuss mechanisms of how disturbed glia/synapse communication can lead to synapse dysfunctions, signaling dysbalance, and neurodegeneration in MS.
DOI of the first publication: 10.3390/ijms24021639
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-387945
ISSN: 1422-0067
Date of registration: 23-Jan-2023
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
Professorship: M - Prof. Dr. Frank Schmitz
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
ijms-24-01639-v2.pdf1,92 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons