Please use this identifier to cite or link to this item: doi:10.22028/D291-38793
Title: THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer
Author(s): Flockerzi, Fidelis Andrea
Hohneck, Johannes
Saar, Matthias
Bohle, Rainer Maria
Stahl, Phillip Rolf
Language: English
Title: Diagnostics
Volume: 13
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: THSD7A
prostate cancer
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Prostate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner. However, a given sub-group has been shown to exhibit aggressive behavior; therefore, it is desirable to find novel prognostic and predictive (molecular) markers. THSD7A expression is significantly associated with unfavorable prognostic parameters in prostate cancer. FAK is overexpressed in several tumor types and is believed to play a role in tumor progression and metastasis. Furthermore, there is evidence that THSD7A might affect FAK-dependent signaling pathways. To examine whether THSD7A expression has an impact on the expression level of FAK in its unphosphorylated form, a total of 461 prostate cancers were analyzed by immunohistochemistry using tissue microarrays. THSD7A positivity and low FAK expression were associated with adverse pathological features. THSD7A positivity was significantly associated with high FAK expression. To our knowledge we are the first to show that THSD7A positivity is associated with high FAK expression in prostate cancer. This might be proof of the actual involvement of THSD7A in FAK-dependent signaling pathways. This is of special importance because THSD7A might also serve as a putative therapeutic target in cancer therapy.
DOI of the first publication: 10.3390/diagnostics13020221
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-387934
ISSN: 2075-4418
Date of registration: 23-Jan-2023
Faculty: M - Medizinische Fakultät
Department: M - Pathologie
Professorship: M - Prof. Dr. Rainer M. Bohle
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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