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|Title:||Bone Healing Gone Wrong : Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors|
Menger, Maximilian M.
Nüssler, Andreas K.
Laschke, Matthias W.
|Year of Publication:||2023|
|Free key words:||bone|
|DDC notations:||610 Medicine and health|
|Publikation type:||Journal Article|
|Abstract:||Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor cells, macrophages, osteoblasts and -clasts, and chondrocytes to restore the osseous tissue. Particularly in long bones including the tibia, clavicle, humerus and femur, this process fails in 2–10% of all fractures, with devastating effects for the patient and the healthcare system. Underlying reasons for this failure are manifold, from lack of biomechanical stability to impaired biological host conditions and wound-immanent intricacies. In this review, we describe the cellular components involved in impaired bone healing and how they interfere with the delicately orchestrated processes of bone repair and formation. We subsequently outline and weigh the risk factors for the development of non-unions that have been established in the literature. Therapeutic prospects are illustrated and put into clinical perspective, before the applicability of biomarkers is finally discussed.|
|DOI of the first publication:||10.3390/bioengineering10010085|
|URL of the first publication:||https://www.mdpi.com/2306-5354/10/1/85|
|Link to this record:||urn:nbn:de:bsz:291--ds-387850|
|Date of registration:||23-Jan-2023|
|Faculty:||M - Medizinische Fakultät|
|Department:||M - Chirurgie|
|Professorship:||M - Prof. Dr. Tim Pohlemann|
|Collections:||SciDok - Der Wissenschaftsserver der Universität des Saarlandes|
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