Please use this identifier to cite or link to this item: doi:10.22028/D291-38785
Title: Bone Healing Gone Wrong : Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors
Author(s): Saul, Dominik
Menger, Maximilian M.
Ehnert, Sabrina
Nüssler, Andreas K.
Histing, Tina
Laschke, Matthias W.
Language: English
Title: Bioengineering
Volume: 10
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: bone
bone healing
fracture
non-union
pseudarthrosis
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor cells, macrophages, osteoblasts and -clasts, and chondrocytes to restore the osseous tissue. Particularly in long bones including the tibia, clavicle, humerus and femur, this process fails in 2–10% of all fractures, with devastating effects for the patient and the healthcare system. Underlying reasons for this failure are manifold, from lack of biomechanical stability to impaired biological host conditions and wound-immanent intricacies. In this review, we describe the cellular components involved in impaired bone healing and how they interfere with the delicately orchestrated processes of bone repair and formation. We subsequently outline and weigh the risk factors for the development of non-unions that have been established in the literature. Therapeutic prospects are illustrated and put into clinical perspective, before the applicability of biomarkers is finally discussed.
DOI of the first publication: 10.3390/bioengineering10010085
URL of the first publication: https://www.mdpi.com/2306-5354/10/1/85
Link to this record: urn:nbn:de:bsz:291--ds-387850
hdl:20.500.11880/34967
http://dx.doi.org/10.22028/D291-38785
ISSN: 2306-5354
Date of registration: 23-Jan-2023
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
Professorship: M - Prof. Dr. Tim Pohlemann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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