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doi:10.22028/D291-38721
Titel: | Sacubitril/valsartan in heart failure : efficacy and safety in and outside clinical trials |
VerfasserIn: | Abdin, Amr Schulz, Martin Riemer, Uwe Hadëri, Bledar Wachter, Rolf Laufs, Ulrich Bauersachs, Johann Kindermann, Ingrid Vukadinović, Davor Böhm, Michael |
Sprache: | Englisch |
Titel: | ESC Heart Failure |
Bandnummer: | 9 |
Heft: | 6 |
Seiten: | 3737-3750 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Heart failure Sacubitril/valsartan Efficacy Effectiveness Safety Implementation |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Heart failure (HF) treatment has changed substantially over the last 30 years, leading to significant reductions in mortality and hospital admissions in patients with HF with reduced ejection fraction (HFrEF). Currently, the optimization of guideline-directed chronic HF therapy remains the mainstay to further improve quality of life, mortality, and HF hospitalizations for patients with HFrEF. The angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (S/V) has an important role in the treatment of patients with HFrEF. The PARADIGM-HF (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) randomized controlled trial has established solid evidence for the treatment of HFrEF in various subgroups. Apart from HFrEF, several studies have been conducted using S/V in various indications: patients hospitalized with acute decompensated HF, HF with preserved ejection fraction, acute myocardial infarction with reduced ejection fraction, uncontrolled and resistant hypertension, and chronic kidney disease. Data from the German Institute for Drug Use Evaluation reveal that implementation of S/V has increased steadily over time and, by the end of 2021, an estimated 266 000 patients were treated with S/V in Germany. The estimated cumulative real-world patient exposure is >5.5 million patient-treatment years worldwide. The number of patients treated with S/V largely exceeds the number of patients treated in clinical trials, and the current indication for S/V is larger than the strict inclusion/exclusion criteria of the randomized trials. Especially elderly patients, women, and patients with more and more severe comorbidities are underrepresented in the clinical trials. We therefore aimed to summarize the importance of S/V in HF in terms of efficacy and safety in clinical trials and daily clinical practice. |
DOI der Erstveröffentlichung: | 10.1002/ehf2.14097 |
URL der Erstveröffentlichung: | https://doi.org/10.1002/ehf2.14097 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-387219 hdl:20.500.11880/34895 http://dx.doi.org/10.22028/D291-38721 |
ISSN: | 2055-5822 |
Datum des Eintrags: | 17-Jan-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fehf2.14097&file=ehf2_14097-sup-0001-Supp.+PubMed+search+strategy_20220224.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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ESC Heart Failure - 2022 - Abdin - Sacubitril valsartan in heart failure efficacy and safety in and outside clinical.pdf | 778,3 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons