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Titel: Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients
VerfasserIn: Kühn, Jan Philipp
Bochen, Florian
Körner, Sandrina
Schick, Bernhard
Wagner, Mathias
Smola, Sigrun
Berkó-Göttel, Barbara
Morris, Luc G. T.
Wang, Jingming
Bozzato, Alessandro
Linxweiler, Maximilian
Sprache: Englisch
Titel: The International Journal of Biological Markers
Bandnummer: 37
Heft: 3
Seiten: 280–288
Verlag/Plattform: Sage
Erscheinungsjahr: 2022
Freie Schlagwörter: Podoplanin
head and neck squamous cell carcinoma (HNSCC)
cancer of unknown primary (CUP)
lymphogenic metastasis
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Introduction: Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnosis. A unique subtype of HNSCC, cancer of unknown primary of the head and neck (HNCUP) is associated with a poor outcome. Increased expression of the D2-40 gene (podoplanin) has been described for several human malignancies and has been associated with increased metastatic potential of cancer cells. Methods: In order to examine the role of podoplanin in lymph node metastasis of HNSCC generally and HNCUP specifically, we evaluated the prognostic impact of podoplanin expression in HNSCC- (n=68) and HNCUP-associated lymph node metastases (n =30). The expression of podoplanin was analyzed by immunohistochemical staining of lymph node tissue samples and correlated with clinical and histopathological data. Results: We found a non-significant tendency towards a higher podoplanin expression in HNCUP compared to HNSCC lymph node metastases and a significant correlation between a high podoplanin expression and advanced node-stage classification. Podoplanin expression had no significant impact on overall survival for both groups and did not correlate with human papillomavirus tumor status. Conclusion: Taken together, our results suggest that upregulation of podoplanin may be associated with a stimulation of lymphatic metastasis in head and neck cancer.
DOI der Erstveröffentlichung: 10.1177/03936155221105524
URL der Erstveröffentlichung: https://doi.org/10.1177/03936155221105524
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-387185
hdl:20.500.11880/34893
http://dx.doi.org/10.22028/D291-38718
ISSN: 1724-6008
0393-6155
Datum des Eintrags: 17-Jan-2023
Bezeichnung des in Beziehung stehenden Objekts: Supplemental material
In Beziehung stehendes Objekt: https://journals.sagepub.com/doi/suppl/10.1177/03936155221105524/suppl_file/sj-tif-1-jbm-10.1177_03936155221105524.tif
https://journals.sagepub.com/doi/suppl/10.1177/03936155221105524/suppl_file/sj-tif-2-jbm-10.1177_03936155221105524.tif
https://journals.sagepub.com/doi/suppl/10.1177/03936155221105524/suppl_file/sj-tif-3-jbm-10.1177_03936155221105524.tif
https://journals.sagepub.com/doi/suppl/10.1177/03936155221105524/suppl_file/sj-docx-4-jbm-10.1177_03936155221105524.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Hals-Nasen-Ohrenheilkunde
M - Infektionsmedizin
M - Medizinische Biochemie und Molekularbiologie
M - Pathologie
Professur: M - Prof. Dr. Bernhard Schick
M - Prof. Dr. Sigrun Smola
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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